EC Microbiology

Salmonella typhi causes typhoid fever, an acute and unknown infection of the reticuloendothelial system that results in significant hepatic problems and biochemical alterations. Although serologic tests are still frequently performed, the diagnostic test of today is the isolation of bacteria from blood, faeces and infrequently, urine. A quick and accurate typhoid fever test still has to be developed. This study illuminates the diagnosis of typhoid fever in resource-limited settings. The present study aimed to evaluate the white blood cell parameters among patients with typhoid fever in Shendi City. This descriptive cross-sectional analytical study was conducted in Shendi Town, River Nile State, from January to April 2025. It included 70 participants: 40 blood samples from typhoid fever patients of different ages and sexes were used as the test group, and 30 healthy individuals were selected randomly as the control group. White blood cell parameters were measured using standard techniques with a CBC automated hematological analyzer (MindaryBC 3000), and the results were analyzed using SPSS 26 for Windows. Results showed that the mean values of white blood cells (4.165), differential counts of lymphocytes and granulocytes (45.8, 11.52, 45.8, 11.52, 41.9), and absolute counts of lymphocytes and granulocytes (1.89, 475, 1.75) in the test group were significantly reduced compared to the mean values of white blood cells (7.19), differential counts of lymphocytes and granulocytes (35.33, 9.347, 56.766), and absolute counts of lymphocytes and granulocytes (7.530, 4.093) in the control group (P < 0.05). In conclusion, typhoid fever affects hematological parameters significantly.

 Keywords: Typhoid; Leukopenia; WBC Parameters; Diagnosis; Shendi

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