EC Microbiology

Short Communication Volume 19 Issue 2 - 2023

Endorphins in Human Wellbeing

Shrihari TG*

Professor, Department of Oral Medicine and Oral Oncology, Krishna Devaraya College of Dental Sciences and Hospital, Bangalore, Karnataka, India

*Corresponding Author: Shrihari TG, Professor, Department of Oral Medicine and Oral Oncology, Krishna Devaraya College of Dental Sciences and Hospital, Bangalore, Karnataka, India.
Received: December 28, 2022;Published: January 27, 2023



Endorphins are endogenous opioids, a neuropeptide, synthesized and stored in the pituitary gland in response to physical stress and pain. Betaendorphin is an abundant endorphin than dynorphins, enkephalins potent than morphine, receptors of endorphins are located on immune cells and nervous system.it has got analgesic, anti-inflammatory, immune stimulatory and stress buster activity can be useful in maintaining holistic health in prevention of diseases. This article briefs about the betaendorphins and its mechanisms of actions in maintaining holistic health.

 

Keywords: Beta-endorphin; Substance p; Dopamine; Opsonin; Granzyme B; IFN-γ

  1. Stojanovich L and Marisavijevich D. “Stress as a trigger of autoimmune disease”. Autoimmunity Reviews 7 (2008): 209-213.
  2. Chaudary SR and Gossman W. “Biochemistry, Endorphin”. Statpearls (2020): 11.
  3. Adeodu OO., et al. “Plasma and Cerebrospinal Fluid Beta-Endorphin Levels Show a Strong Association in Children with Cerebral Malaria”. Journal of Pediatric Neurosciences4 (2018): 416-422.
  4. Shenoy SS and Lui F. “Biochemistry, Endogenous Opioids”. Stat Pearls. Stat Pearls Publishing; Treasure Island (FL) (2020).
  5. Olson KM., et al. “Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain”. Yale Journal of Biology and Medicine1 (2017): 97-110.
  6. Stefano GB., et al. “Opioid and Opiate Immunoregulatory Processes”. Critical Reviews in Immunology2-6 (2017): 213-248.
  7. Remesic M., et al. “Cyclic Opioid Peptides”. Current Medicinal Chemistry13 (2016): 1288-1303.
  8. Gein SV. “Dynorphins in regulation of immune system functions”. Biochemistry5 (2014): 397-405.
  9. Giri AK and Hruby VJ. “Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of pain”. Expert Opinion on Investigational Drugs2 (2014): 227-241.
  10. Yoo JH., et al. “The endogenous opioid system in cocaine addiction: what lessons have opioid peptide and receptor knockout mice taught us?” British Journal of Pharmacology7 (2012): 1993-2014.
  11. Rodriguez FD and Coveñas R. “Targeting opioid and neurokinin-1 receptors to treat alcoholism”. Current Medicinal Chemistry28 (2011): 4321-4334.
  12. Gentilucci L., et al. “Peptides and peptidomimetics in medicine, surgery and biotechnology”. Current Medicinal Chemistry20 (2006): 2449-2466.
  13. Brownson EA., et al. “Effect of peptidases at the blood brain barrier on the permeability of enkephalin”. Journal of Pharmacology and Experimental Therapeutics 270 (1994): 675-680.
  14. Deakin JF., et al. “Influence of N-terminal acetylation and C-terminal proteolysis on the analgesic activity of beta-endorphin”. Biochemical Journal 189 (1980): 501-506.
  15. Hutchinson MR., et al. “Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)”. European Journal of Neuroscience 28 (2008): 20-29.
  16. Jaba I., et al. “Variation in the analgesic activity of opioid peptide fragments in correlation with the amino acidic sequence”. European Journal of Medicine 2 (2007): 417-429.
  17. Kovalitskaya YA and Navolotskaya EV. “Nonopioid effect of β-endorphin”. Biochemistry 76 (2011): 379-393.
  18. Morgan M., et al. “Dynorphin A 1–17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography–tandem mass spectrometry”. Analytical and Bioanalytical Chemistry 404 (2012): 3111-3121.
  19. Reed B., et al. “Extracellular biotransformation of β-endorphin in rat striatum and cerebrospinal fluid”. Journal of Neuroendocrinology 20 (2008): 606-616.
  20. Shrihari TG. “Endorphins- A novel hidden magic holistic healer”. Journal of Clinical and Cellular Immunology2 (2008): 547-552.
  21. Shrihari TG. “Endorphins- A forgotten hidden magic holistic healer: Minireview”. Advanced Complement and Alternative Medicine5 (2018): 1-4.
  22. Shrihari TG. “Beta-Endorphins- A novel natural holistic healer”. Journal of Microbial and Biochemical Technology2 (2018): 10-14.
  23. IwaszkiewicZ KS., et al. “Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions”. Frontiers in Pharmacology4 (2013): 132-137.

Shrihari TG. “Endorphins in Human Wellbeing”. EC Microbiology  19.2 (2023): 17-19.