EC Microbiology

Editorial Volume 18 Issue 12 - 2022

Deficiency of Vitamin D and Related Disorders

Nadira A Al-Baghl1*, Amani Hashim Mahdi2, Ghada Fareed Hussain Qutub3, Ahmed Abdulrahman Alanazi4, Mohammed Sameer Alabbad5, Hassan Abdulrahman Eissa6, Maram Abdulrahman Aldahoos7, Futun Thamer Almutiri8, Bayan Lafi Altamimi9, Mohammed Ahmed Alqubali10, Zainab Jaffer A Alshaikh7, Kawther Ahmed Al Rebh11, Abdulmajed Mohammad A. Alrawail12 and Nouf Khalid Alalshaikh13

1Director of Public Health Network, Dammam, Saudi Arabia

2National Guard Hospital, Jeddah, Saudi Arabia

3Umm Alqura University, Makkah, Saudi Arabia

4Medical University of Lublin, Poland

5Aljafer General Hospital, Alahsa, Saudi Arabia

6Khafji General Hospital, Khafji, Saudi Arabia

7Safwa General Hospital, Safwa, Saudi Arabia

8Maternity and Children Hospital, Al Kharj, Saudi Arabia

9King Fahad Hospital, Madinah, Saudi Arabia

10Prince Sultan Military Medical City, Riyadh, Saudi Arabia

11Alaqrabya Primary Healthcare, Khobar, Saudi Arabia

12Northern Border University, Arar, Saudi Arabia

13King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia

*Corresponding Author: Nadira A Al-Baghl, Fellowship Family and Community Medicine, Master Professions Medical Education - Public Health, Director of Public Health Network, Dammam, Saudi Arabia.
Received: December 21, 2022; Published: December 26, 2022

Introduction: Vitamin D is responsible for maintaining the metabolism of calcium and phosphate and preserving a healthy, mineralized skeleton. Also known as an immunomodulatory hormone. The active form of vitamin D, 1,25-dihydroxy vitamin D, has been demonstrated in experimental experiments to exhibit immunologic effects on a number of innate and adaptive immune system components as well as endothelial membrane integrity. Low serum 25-hydroxyvitamin D levels have been linked to an increased risk of acquiring a number of immune-related conditions and diseases, including psoriasis, type 1 diabetes, multiple sclerosis, rheumatoid arthritis, TB, sepsis, respiratory infection, and COVID-19. As a result, a number of clinical trials with varying results have been carried out to ascertain the effectiveness of administering vitamin D and its metabolites for the treatment of these diseases. Recent research reveals that certain people may benefit from vitamin D supplementation more or less than others. Vitamin D administration has been shown to significantly alter broad gene expression in human peripheral blood mononuclear cells. Although the ideal level of serum 25-hydroxyvitamin D is still up for debate, it is advised to increase vitamin D intake and get enough sunlight exposure to keep serum 25-hydroxyvitamin D levels at least at 30 ng/mL (75 nmol/L), and ideally at 40 - 60 ng/mL (100 - 150 nmol/L), in order to reap the most benefits for your overall health.

Aim of the Study: The aim of the present review is to understand various disorders related to Vitamin D deficiency.

Methodology: Comprehensive research of the various disorders related to Vitamin D deficiency. PUBMED engine was the database used for the search process, and articles were collected from 2011 to 2022. The term used in the search were: Vitamin D, immune diseases, depression, infection.

Conclusion: Unquestionably, vitamin D is crucial for maintaining the metabolism of calcium, phosphate, and bone. Once a 1,25(OH)2D is created, it modulates the innate and adaptive immune systems in an autocrine and paracrine manner. Additionally, there is some proof that vitamin D may modify immune activity in a non-genomic way by maintaining endothelium membranes. The majority of the available research points to the necessity of maintaining a healthy vitamin D status for controlling the body's immune system. Many immune-related diseases, including autoimmune disorders and infectious diseases, are linked to low serum levels of 25(OH)D. With a few exceptions noted in this study, there is less compelling evidence that vitamin D is a useful therapeutic option for autoimmune illnesses and infectious diseases. Based on inconsistent results from clinical trials, it is still debatable whether vitamin D therapy is beneficial as an additional immunomodulatory drug for treating the majority of illnesses.


Keywords: Vitamin D; Immune Diseases; Depression; Infection

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Nadira A Al-Baghl., et al. “Deficiency of Vitamin D and Related Disorders”. EC Microbiology  18.12 (2022): 69-76.