EC Microbiology

This review article aims to help patients with chronic constipation and prevent serious consequences. We evaluate the causes that must be addressed to prevent or reduce this unpleasant process. We begin with a review of the pathophysiology to understand what is happening and lay the groundwork for correction. We continue with a widely accepted concept: the correlation between the intestinal microbiome and chronic constipation, which can be for better or worse. Next, we consider intestinal dysbiosis, which accompanies the process, and how to address it. We continue with analysis of short-chain fatty acids, secondary bile acids and, microbiota metabolites, which have a variable impact on chronic constipation. We continue with topic of how the intestinal membrane is affected in chronic constipation and what can develop, such as the passage of pathogenic bacteria through it, with the resulting consequences. We review whether various biotics should be provided, such as pre-, pro-, and symbiotics, as well as postbiotics, psychobiotics, and bacteriophages. We conclude with the importance of intestinal microbiota transplantation.

 Keywords: Chronic Constipation (Cconst); Gut Microbiome (GM); Gut Dysbiosis (ID); Biotics (Biot); Fecal Microbiota Transplantation (FMT)

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