EC Microbiology

Silicone lymphadenopathy emerges as an exceptionally observed. Enlargement of regional lymph nodes induced by amalgamation of silicone particles traversed from tributary organs into lymph node parenchyma. The condition may arise as an incidental feature or may engender a painful and enlarged lymph node. Silicone lymphadenopathy may be concurrent with granulomatous inflammation of the lymph node. Silicone associated lymphadenopathy is commonly confined to lymph nodes draining the implant site, especially axillary lymph nodes.

1. Zhang X., et al. “Silicone lymphadenopathy: A case report and literature review”. Medicine (Baltimore)1 (2026): e46777.
2. Bui J., et al. “Diagnostic dilemma of silicone-induced ipsilateral internal mammary lymphadenopathy mimicking breast cancer recurrence after mastectomy: a case report”. Journal of Medical Case Reports 1 (2026): 69.
3. Rosenthal A., et al. “Silicone lymphadenopathy following augmentation mammoplasty with silicone implants”. Aesthetic Surgery Journal 11 (2024): 1167-1175.
4. Avgeri CT., et al. “Silicone cervical lymphadenopathy: a rare complication after breast augmentation”. Cureus 12 (2023): e50453.
5. Zhong H., et al. “Monomorphic epitheliotropic intestinal T-cell lymphomas: a case report”. Diagnostic Pathology 16 (2021): 80.
6. Veloza L., et al. “Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome”. Haematologica1 (2022): 181-195.
7. Van Bockstal MR., et al. “Breast-implant related silicone lymphadenopathy: asteroid bodies do not always equal sarcoidosis!”. International Journal of Surgical Pathology 6 (2023): 1099-1104.
8. Klang E., et al. “Detection of pathologically proven silicone lymphadenopathy: ultrasonography versus magnetic resonance imaging”. Journal of Ultrasound in Medicine 4 (2018): 969-975.
9. Li SJ., et al. “Enlarging internal mammary silicone lymphadenopathy mimicking breast metastases”. Journal of Medical Imaging and Radiation Oncology 2 (2020): 216-218.
10. Cho E., et al. “Silicone‐induced lymphadenopathy mimicking recurrence of breast cancer on positron emission tomography‐computed tomography, correctly diagnosed on ultrasound”. Journal of Clinical Ultrasound 6 (2021): 610-613.
11. Chae RP., et al. “Progressive silicone lymphadenopathy post mastectomy and implant reconstruction for breast cancer”. BMJ Case Reports 2 (2021): e237711.
12. Quesada AE., et al. “Breast implant-associated anaplastic large cell lymphoma: a review”. Modern Pathology 2 (2019): 166-188.
13. Image 1 Courtesy: Pathology outlines.
14. Image 2 Courtesy: Basic Medical Key.