EC Microbiology

A clinical phenomenon known as neonatal sepsis is characterized by infection-related signs and symptoms in the first month of life, either with or without bacteremia. The main objective of the present study was to study the role of Toll-like receptors as a diagnostic marker for neonatal bacterial sepsis and its possibilities for differentiation between viral and bacterial neonatal infections. To gather information from patients, a cross-sectional study design was used. Study sample included 50 neonates who were categorized as a low-risk group and a high risk-group for sepsis. Both blood cultures and toll like receptors were investigated. Results showed that 18% of blood culture were positive, and the most prevalent bacterium was Group B Streptococcus. Comparing high-risk group with low-risk group for toll like receptors, CRP, and WBC showed that TLRs, CRP were higher in high-risk group compared with low-risk group (p < 0.05), except the levels of WBC that did not show significant variations (p = 0.072). Together, the study's findings showed how crucial it is to use toll-like receptors for diagnostic purposes.

Keywords: Neonatal Sepsis; Blood Culture; Group B Streptococcus; Toll Like Receptor; Diagnostic Marker

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