Clinical Review Volume 8 Issue 8 - 2025

Application of Aloe Vera Juice as an Adjuvant for Adult Depressive People to Pseudo-Dementia People in a Long Period. Case Report 1-2

A Yagi1* and M Hasegawa2

1Emeritus Professor, Fukuyama University, Hiroshima, Japan; Special adviser of Japan Aloe Science Association, Japan

2Kampo-Pharmacy Grace Meg Saron, owner, Toshima, Tokyo, Japan

*Corresponding Author: A Yagi, Emeritus Professor, Fukuyama University, Hiroshima, Japan; Special adviser of Japan Aloe Science Association, Japan.
Received: June 30, 2025; Published: July 29, 2025



Aloe vera juice (AVJ) in long term-ingestion improved older people diagnosed of multi-pharmacy. AVJ containing essential amino acids with a mucopolysaccharide, acemannan, as a precipitation-type adjuvant, could suggest to support the recovery of pseudo-dementia in older people.

 Keywords: AVJ Long Term-Ingestion; Diagnosed Dementia; Multi-Pharmacy; Older People; Recovery Mental Health

  1. H Suzuki., et al. “Intake of seven essential amino acids improves cognitive function and psychological and social function in middle-aged and older adults: A double blind, randomized, placebo-controlled trial”. Frontiers in Nutrition 7 (2020): 586166.
  2. A Surjushe., et al. “Aloe vera: A short review”. Indian Journal of Dermatology 4 (2008): 161-166.
  3. T Reynolds. “Compounds in Aloe leaf exudates: a review”. Botanical Journal of Linnean Society3 (2008): 157-177.
  4. MD Bouldreau., et al. “Toxicology and carcinogenesis studies of a noncolored whole leaf extract of Aloe vera in F344/N rat and B6C3F1 mice”. National Toxicology Program Technical Report Series 577 (2013): 1-266.
  5. Khaksari M., et al. “Aloe vera leaf extract reduced blood brain barrier permeability and improved neurological result after traumatic brain injury: The role of oxidative stress”. Oxidative Medicine and Cellular Longevity (2024): 5586814.
  6. A Yagi., et al. “Contribution of an adjuvant, Aloe vera juice to multi-pharmacy-derived constipation in old patients with deep sleeping, gut-circumstance-development and QOL: Case reports 1-3”. ECCMC Clinical and Medicine7 (2025): 01-02.
  7. M Sanchez., et al. “Pharmacological update properties of Aloe vera and its major active constituents”. Molecules 6 (2020): 1324.
  8. Rizkiyanti Putriet., et al. “Extraction of hyaluronic acid from aloe vera”. Journal of Functional Food and Nutraceutical 2 (2020): 23-30.
  9. A Yagi., et al. “Prophylactic role of Aloe components, butyrate fermented, microRNAs, and hyaluronan on Alzheimer’s disease, Parkinson’s disease, and osteoarthritis in knee joints: Case reports of Aloe vera juice ingestion producing intestinal butyrogenic microbiome and bone regeneration”. Journal of Gastroenterology and Hepatology Research 1 (2021): 3388-3398.
  10. A Yagi., et al. “Isolation and characterization of the glycoprotein fraction with a proliferation promoting activity on human and hamster cells in vitro from Aloe vera gel”. Planta Medica1 (1997): 18-21.
  11. Swagata Das., et al. “Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel”. International Journal of Biological Macromolecules1 (2011): 38-42.
  12. A Yagi., et al. “Radical scavenging glycoprotein inhibitory Cox 2 and TxA2 synthesis from Aloe vera gel”. Planta Medica3 (2003): 269-271.
  13. J-M Yun., et al. “A randomized placebo-controlled crossover trial of Aloe vera on bioavailability of vitamin C and B12, blood glucose, and lipid profile in healthy human subjects”. Journal of Dietary Supplements 2 (2010): 145-153.
  14. HA-El-Shemy., et al. “Anti-tumor properties and modulation of antioxidant enzyme’ activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction”. Current Medicinal Chemistry 2 (2010): 129-138.

A Yagi and M Hasegawa. “Application of Aloe Vera Juice as an Adjuvant for Adult Depressive People to Pseudo-Dementia People in a Long Period. Case Report 1-2”. EC Clinical and Medical Case Reports  8.8 (2025): 01-04.