EC Clinical and Medical Case Reports

Research Article Volume 9 Issue 2 - 2026

Ab Initio Whole Cell Kinetic Model of Corynebacterium accolens DSM 44278 (caccSM26)

Sohnnakshee Murugesu1,2, Tristan Zhi Xian Tay1,2, Magaa Lakshmi Dhinakaran1,2, Aguilar Normi Luisa Cinco1,2, Pandiyan Srinithiksha1,2 and Maurice Han Tong Ling2,3,4*

1School of Health and Life Sciences, Teesside University, UK

2Management Development Institute of Singapore, Singapore

3Newcastle Australia Institute of Higher Education, University of Newcastle, Australia

4HOHY PTE LTD, Singapore

*Corresponding Author: Maurice Han Tong Ling, Newcastle Australia Institute of Higher Education, University of Newcastle, Australia.
Received: January 09, 2026; Published: January 28, 2026



Corynebacterium accolens DSM 44278 is a nasal commensal with emerging probiotic potential and relevance to respiratory health, including interactions with respiratory pathogens in the upper airway. These properties make C. accolens a promising candidate for metabolic engineering, which can benefit from a whole-cell kinetic model to evaluate various engineering proposals in silico. However, there is currently no reported whole-cell kinetic model for C. accolens. Therefore, this study constructs a whole-cell simulatable kinetic model of C. accolens DSM 44278 using an ab initio approach by identifying enzymes from its reference genome. The resulting model, caccSM26, comprises 1097 metabolites, 407 enzymes with associated transcription and translation processes, and 1182 enzymatic reactions represented as ordinary differential equations using representative kinetic parameters. This whole-cell kinetic model serves as a foundational framework for future refinement with organism-specific data and for in silico exploration of growth behaviour, regulatory mechanisms, and metabolic engineering strategies in this clinically relevant commensal.

 Keywords: Whole-Cell Model; Kinetic Model; Differential Equations; AdvanceSyn Toolkit

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Maurice Han Tong Ling., et al. “Ab Initio Whole Cell Kinetic Model of Corynebacterium accolens DSM 44278 (caccSM26)”. EC Clinical and Medical Case Reports  9.2 (2026): 01-06.

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