Case Report Volume 8 Issue 8 - 2025

A Rare Gestational Trophoblastic Disease with Lung Metastases: A Case Report and Literature Review

Okello Malcom Mark1,2*, Musoke Sharrif1, Alele David1, Mawanda Anatoli1,2,3,4, Omega Phillip1,2,6, Boaz Mwesigwa1,4,5, Tonny Okecha2,3, Nassolo Sheila7, Nakiyinji Lydia7, Lukande Robert2 and Kalungi Sam1,2

1Department of Pathology, Mulago National Referral Hospital, Uganda

2Department of Pathology, Makerere University, Uganda

3Department of Pathology, Uganda Cancer Institute, Uganda

4Department of Pathology, King Ceasor University, Uganda

5Department of Biomedical Laboratory Technology and Molecular Biology, Makerere University, Uganda

6Department of Pathology, St. Mary’s Hospital Lacor, Uganda

7Department of Internal Medicine, Makerere University, Uganda

*Corresponding Author: Okello Malcom Mark, Department of Pathology, Makerere University, Uganda. Email: okellomalcom@gmail.com
Received: July 06, 2025; Published: August 06, 2025



We present a postmortem case report of a 42-year-old female, who passed away 3 days post-admission following severe respiratory distress. She was 4 months postpartum after an emergency cesarean section due to fetal distress and had a 3-week history of difficulty in breathing, associated with dyspnea, hemoptysis, pleuritic chest pain, orthopnea, palpitations, and dizziness. On examination, she presented with severe respiratory distress, pallor, tachycardia, and coarse bilateral crepitations on auscultation. A working diagnosis of gestational trophoblastic disease (GTD) with lung metastases complicated by Anemia was made. Differential diagnoses included pulmonary tuberculosis, pulmonary embolism, bacterial pneumonia, congestive heart failure, and antiphospholipid syndrome. Despite treatment with oxygen therapy and antibiotics, the patient deteriorated and was declared dead following unsuccessful cardiopulmonary resuscitation. Postmortem histopathological examination confirmed a diagnosis of placental site trophoblastic tumor (PSTT) with metastases to the lungs and liver. This case highlights the diagnostic challenge posed by GTD in resource limited setting such as Uganda, and clinicians must always have suspicion in such present with lung metastases and emphasizes the importance of early recognition and management.

 Keywords: Placental Site Trophoblastic Tumor; Postmortem Diagnosis; Lung Metastases; Gestational Trophoblastic Disease; Postpartum Complications

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Okello Malcom Mark., et al. “A Rare Gestational Trophoblastic Disease with Lung Metastases: A Case Report and Literature Review”. EC Clinical and Medical Case Reports  8.8 (2025): 01-08.