EC Cancer

Primary hepatic lymphoma (PHL) is a rare malignancy that can mimic hepatic metastases, particularly in patients with known primary cancers such as colorectal and bladder carcinomas. We report the case of a 68-year-old patient with a history of colorectal adenocarcinoma and urothelial bladder carcinoma, who presented with a hypodense hepatic lesion initially suspected to be metastatic. Histopathological examination and immunohistochemistry of the liver biopsy confirmed a diagnosis of diffuse large B-cell lymphoma, germinal center subtype. PET/CT imaging revealed no extrahepatic involvement. This case highlights the diagnostic challenges of PHL and emphasizes the importance of histological confirmation to distinguish it from metastatic disease, ensuring appropriate therapeutic management. Multidisciplinary collaboration is essential to optimize patient outcomes.

 Keywords: Primary Hepatic Lymphoma; Liver Biopsy; Rare

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