EC Pharmacology and Toxicology

Research Article Volume 13 Issue 6 - 2025

Studies on Water-Harvesting Ponds (Haffirs) in Gedarif State, Eastern Sudan: IV. Registry of Cancer Cases and Kidney Problems Reported in Gedarif State and their Relations to the Detected Pollutants

Nabil H H Bashir1*, Ibrahim FAE1 and Bashier EE2

1Blue Nile National Institute for Communicable Diseases (BNNICD), Sudan
2Water Management and Irrigation Institute, University of Gezira, Wad Medani, Sudan

*Corresponding Author: Nabil H H Bashir, Blue Nile National Institute for Communicable Diseases (BNNICD), Sudan.
Received: April 30, 2025; Published: May 26, 2025



The water harvesting ponds (haffirs) are used for drinking, agriculture, domestic needs and activities. These haffirs are designed to store water to be used during the dry-season in Sudan. The objectives of the series of the 4 previously published studies were to investigate the possibility of pollution hazardous materials like heavy metals (HMs), pesticides and hydrocarbons (HCs) and relate them to the registry of cancer and renal problem cases of Gedarif State (GS), Eastern Sudan. Three haffirs, representing 3 regions within the state, were subjected to the investigations, viz. Azaza, Tarfa and Elkafay. The HMs results showed that levels of several of them were higher than the WHO permissible levels (PLs) in the soil and water. The herbicide 2,4-D, and the insecticides carbaryl, lindane, their degradation products, in addition to some hydrocarbons were detected. It is concluded that the levels of some of these pollutants might be behind the incidence of some of the reported cancers and the renal failure cases in the area. The study recommended that haffirs site selection, design, facilities, logistics and protection must be given the required attention by all stakeholders.

 Keywords: Water-Harvesting; Heavy Metals; Carbaryl; Lindane; 2,4-D; Cancer; Renal Problems; Gedarif State; Sudan

  1. Ibrahim FAE. “Determination of chemical pollution in water-harvesting reservoirs (haffirs) water and soil of Al Gadarif State, Eastern Sudan”. Ph.D. Dissertation, University of Gezira, Sudan (2019).
  1. Ibrahim FAE., et al. “Heavy Metals in Water Collected from Water-harvesting Ponds (Haffirs), Gedarif State, Eastern Sudan”. EC Pharmacology and Toxicology 12 (2019): 01-08.
  2. Bashir NHH., et al. “Studies on Water-Harvesting Ponds (Haffirs) in Gedarif State, Eastern Sudan: I. Determination of Haffir Soil Heavy Metals”. EC Pharmacology and Toxicology11 (2024): 01-11.
  3. Bashir NHH., et al. “Studies on Water-Harvesting Ponds (Haffirs) in Gedarif State, Eastern Sudan: II. Determination of Haffir Water Heavy Metals using ICP-OES vs. Atomic Absorption Spectrometry”. EC Pharmacology and Toxicology 12 (2024): 01-08.
  4. Orhue ER and Frank UO. “Fate of some heavy metals in soils: a review”. Journal of Applied and Natural Science1 (2011): 131-138.
  5. Eltohami MME., et al. “Effect of Some Professions on the Lead Levels of Male Urine in Wad-Medani, Sudan”. EC Pharmacology and Toxicology4 (2017): 150-157.
  6. Eltohami MME., et al. “Lead Levels in the Urine of Males and Females from Different Age-groups in an Agricultural Village and Sugar-producing Town in the Gezira State, Central Sudan”. EC Pharmacology and Toxicology 1 (2017): 13-20.
  7. Eltohami MME., et al. “Cadmium Levels in the Urine of Males and Females from Different Age-groups in an Agricultural Village and Sugar-Producing Town in the Gezira State, Central Sudan”. EC Pharmacology and Toxicology3 (2018): 120-127.
  8. Hassan ME., et al. “Sugar Industry as a Source of Pollution: A Case Study, Elgenaid Sugar Factory, Gezira State, Sudan”. EC Pharmacology and Toxicology5 (2017): 202-212.
  9. Abdalla AMS., et al. “Heavy Metals Concentrations in Drinking Water in Dongola and Merowe, Northern State, Sudan”. EC Pharmacology and Toxicology9 (2018): 829-837.
  10. Abdelbagi AO., et al. “Impact of Pesticides and other Chemicals on the Environment. Report of the United Nations Conference on Environment and Development, Rio de Janeiro, 3(14, vol. I, Resolutions adopted by the Conference (United Nations publication, Sales No. E.93.I.8 and corrigendum), resolution 1, annex II (1992).
  11. Abdelbagi A O., et al. “Organochlorine insecticides residues in Sudanese soil of intensive pesticide use and in surface soil of Qurashi pesticide store”. University of Khartoum Journal of Agricultural Sciences 11 (2003): 59-68.
  12. Stockholm Convention on Persistent Organic Pollutants (POPs). Text and annexes. UNEP and FAO (2001).
  13. Thapa B., et al. “A Review on bioremediation of petroleum hydrocarbon contamination in soil”. Kathmandu University Journal of Science, Engineering and Technology1 (2012): 164-170.
  14. Banerjee A., et al. “Bioremediation of hydrocarbon - A Review”. International Journal of Advanced Research 6 (2016): 1303-1313.
  15. Osman HE., et al. “Usage of some agricultural by-products in the removal of some heavy metals from industrial wastewater”. Journal of Phytology3 (2010): 51-62.
  16. Järup L. “Hazards of heavy metal contamination”. British Medical Bulletin 1 (2003): 167-182.
  17. Ferner DJ. “Toxicity of heavy metals”. eMedicine Journal5 (2001): 1.
  18. Noorani R. “Heavy metals and cancer”. Division of Cancer Epidemiology, McGill University (2023).
  19. Sharma B., et al. “Biomedical implications of heavy metals induced imbalances in redox systems”. BioMed Research International (2014): 640754.
  20. Johnson MD., et al. "Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland". Nature Medicine 8 (2003): 1081-1084.
  21. Mohan S and Sreelakshmi G. “Fixed bed column study for heavy metal removal using phosphate treated rice husk”. Journal of Hazardous Materials 1-2 (2008): 75-82.
  22. Ismail A., et al. “Concentrations of Cd, Cu and Zn in sediments collected from urban lakes at Kelana Jaya, Peninsular Malaysia”. Wetland Science4 (2004): 248-258.
  23. Tetens I., et al. “The impact of a meat- versus a vegetable-based diet on iron status in women of childbearing age with small iron stores”. European Journal of Nutrition 8 (2007): 439-445.
  24. Vouk VB and Nieboer P. “Vanadium in the environment and its toxicological significance”. Science of the Total Environment 10 (1979): 1-88.
  25. Yang K., et al. “Characteristics of heavy metal contamination by anthropogenic sources in artificial lakes of urban environment”. KSCE Journal of Civil Engineering1 (2015): 121-129.
  26. Genchi G., et al. “Nickel: Human health and environmental toxicology”. International Journal of Environmental Research and Public Health 3 (2020): 679.
  27. Xia Wang., et al. “Nonlinearity association of blood cobalt with the risk of anemia among middle-aged and older adults: National Health and Nutrition Examination Survey”. Hematology1 (2024): 2416724.
  28. Toxicological profile of molybdenum: draft for public comment. US Department of Health and Human Services April (2017).
  29. Márquez-Ramírez SG., et al. “Titanium dioxide nanoparticles inhibit proliferation and induce morphological changes and apoptosis in glial cells”. Toxicology2-3 (2012): 146-156.
  30. Skocaj M., et al. “Titanium dioxide in our everyday life; is it safe?” Radiology and Oncology 4 (2011): 227-247.
  31. Murthy HMR and Manonmani HK. “Aerobic degradation of technical hexachlorocyclohexane by a defined microbial consortium”. Journal of Hazardous Materials 1 (2007): 18-25.
  32. Carbaryl. International Programme on Chemical Safety Poisons Information Chemica Monograph 147) l (1994).
  33. Swetha PV and Phale PS. “Metabolism of carbaryl via 1,2-dihydroxynaphthalene by soil isolates Pseudomonas strains C4, C5, and C6”. Applied and Environmental Microbiology 71.10 (2005): 5951-5956.
  34. Venkateswarlu K., et al. “Persistence and biodegradation of carbaryl in soils”. Journal of Environmental Science and Health B 15.4 (1980): 421-429.
  35. International Agency for Research on Cancer. IARC Summary and Evaluation-Carbaryl, Suppl. 7; WHO Geneva, Switzerland, Volume 12 (1987).
  36. Ghassemi M., et al. “Environmental Fates and Impacts of Major Forest Use Pesticides”. Report by TRW Environmental Division for the U.S. Environmental Protection Agency, Contract #68-02-3174, Work Assignments Nos. 13 (1981).
  37. 2,4-D Technical Fact Sheet. Oregon State University, USA (2008).
  38. Wafa T., et al. “Environmental fate and effects of 2,4-dichlorophenoxy acetic acid herbicide”. In: Herbicides: Properties, Crop Protection. Editor: Karl D. Piotrowski. Nova Science Publishers, Inc (2011): 245-262.
  39. 2,4-D amine 4. Revised for GHS Compliance (2014).
  40. Health Canada. Consultation: 2,4-Dichlorophenoxyacetic acid (2,4-D) in drinking water-Guideline technical document (2020).
  41. Environmental Health Criteria 84, Environmental Aspects - 2,4-Dichlorophenoxyacetic acid (2,4-D); International Programme on Chemical Safety, World Health Organization: Geneva, Switzerland (1989).
  42. Reregistration Eligibility Decision (RED) 2,4-D; EPA 738-R-05-002; U.S. Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances, Office of Pesticide Programs, U.S. Government Printing Office: Washington, DC (2005).
  43. Curtis J., et al. “Hydrocarbon Toxicity”. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing (2023).

Nabil H H Bashir., et al. "Studies on Water-Harvesting Ponds (Haffirs) in Gedarif State, Eastern Sudan: IV. Registry of Cancer Cases and Kidney Problems Reported in Gedarif State and their Relations to the Detected Pollutants". EC Pharmacology and Toxicology 13.6 (2025): 01-10.