EC Pharmacology and Toxicology

Research Article Volume 8 Issue 11 - 2020

Ricinodendron heudelotii Extract Strongly Protects Mice against Acetaminophen-Induced Liver Injury

Agathe Lambou Fotio1*, Paul Aimé Noubissi1, Joseph Mukam Ngakou2, Mireille Sylviane Dongmo Nguepi3, Roméo Joel Guemmogne Temdie4, Theophile Dimo2, René Kamgang2,5 and Telesphore Benoit Nguelefack6

1Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, Buea, Cameroon
2Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
3Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, Cameroon
4Department of Biological Sciences, Faculty of Science, University of Ngaoundere, Ngaoundere, Cameroon
5Laboratory of Endocrinology and Radioisotopes, Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaounde, Cameroon
6Department of Animal Biology, Faculty of Science, University of Dschang, Dschang, Cameroon

*Corresponding Author: Agathe Lambou Fotio, Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, Buea, Cameroon.
Received: August 29, 2020; Published:October 07, 2020



Ricinodendron heudelotii (Baill.) Pierre ex Pax. (Euphorbiaceae) is used in Cameroonian traditional medicine to cure liver diseases, malaria, and stomach pain. The present study investigates the effect of R. heudelotii stem bark aqueous extract on acetaminophen-induced acute liver injury in BALB/c mice.

  1. heudelotii stem bark aqueous extract (100 and 200 mg/kg, p.o.), distilled water and ascorbic acid (50 mg/kg, p.o.) were administered to mice 1 and 12h before liver injury induction by acetaminophen (500 mg/kg, p.o.). Mice were sacrificed 6h later. Biochemical and histological analyses were used to assess liver injury.

Acetaminophen administration resulted in significant (P < 0.01) increase of liver relative weight, liver enzymes [aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP)] serum activities, nitrite and malondialdehyde (MDA) liver content. R. heudelotii extract significantly (P < 0.05) reduced ALT and ALP serum activity, MDA and nitrite’s liver content, compared to acetaminophen-treated mice. In addition, R. heudelotii extract significantly (P < 0.05) prevented depletion of reduced glutathione (GSH) in mice liver. Tumor necrosis factor alpha (TNF-α or TNF) and Interleukin one beta (IL-1β) serum levels were also reduced (P < 0.05) by R. heudelotii extract. Histological injuries by acetaminophen were remarkably reduced by plant extract administration.

The results revealed that R. heudelotii stem bark aqueous extract could provide protection against acetaminophen hepatotoxicity that may be related to its antioxidant and anti-inflammatory properties. The results strongly support the ethnopharmacological uses of R. heudelotii.

Keywords: Ricinodendron heudelotii; Acetaminophen; Liver Injury; GSH; Anti-Inflammatory; Anti-Oxidant

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Agathe Lambou Fotio.,et al. Pharmacotherapy and Drug Usage in Children. EC Pharmacology and Toxicology 8.11 (2020): 01-13.

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