Medical Services Directorate, Pharmacy Department, Collaborative Researcher, King Abdulaziz University, Department of Clinical Pharmacology, Faculty of Medicine Jeddah, Saudi Arabia
Background: The convergence of quantum pharmacology and smart protein engineering has established a novel paradigm-Quantum Smart Protein Therapeutics (QSPT). QSPT may represent a potential shift from generalized pharmacological interventions toward precisely tailored therapies, designed and validated through quantum simulations, artificial intelligence, and synthetic biology. This paradigm may offer novel approaches to complex and resistant diseases by leveraging atomic-level modeling of drug-target interactions [1].
Objective: To define and establish the foundational framework of QSPT, integrating the theoretical principles of quantum pharmacology with the applied innovation of smart proteins. The aim is to support a universal, adaptable therapeutic platform capable of addressing diverse diseases with individualized precision.
Methods: QSPT integrates quantum simulations of molecular dynamics, AI-based protein design, and pharmacometric modeling. The approach includes: Electronic structure optimization using quantum mechanics; Smart protein folding and domain generation using AI; In silico validation of pharmacokinetics and pharmacodynamics through PBPK, PopPK, and quantum-corrected models.
Results: Simulations suggest potential therapeutic advantages, subject to further validation: Gentamicin QSP: Reduced nephrotoxicity and enhanced bacterial targeting; Vancomycin QSP: Improved antimicrobial precision and lowered resistance potential; Cisplatin QSP: Renal-sparing tumor delivery; GLP-1 QSP: Improved oral bioavailability and glycemic control; CF/SMA Proteins: Potential non-genomic modulation of inherited disease pathways, pending experimental validation.
Conclusion: QSPT is being explored as a developing therapeutic concept currently under institutional evaluation and proposed for intellectual property protection. It offers scalable, programmable, patient-specific treatment solutions. Its cross-disciplinary integration supports the development of future clinical simulators, diagnostic-therapeutic systems, and multinational medical platforms. This paper proposes QSPT as a potentially valuable framework for future biomedical innovation.
Keywords: Quantum Smart Protein Therapeutics; Next-Generation Drug Design; Personalized Therapeutics
Khalid A Al-Faifi. “Quantum Smart Protein Therapeutics: A Foundational Discipline for Next-Generation Drug Design and Personalized Therapeutics”. EC Pharmacology and Toxicology 13.8 (2025): 01-09.
© 2025 Khalid A Al-Faifi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Open Access by ECronicon is
licensed under a Creative Commons Attribution
4.0 International License
Based on a work at www.ecronicon.net