EC Pharmacology And Toxicology

Research Article Volume 11 Issue 6 - 2023

Protective Effect of Vitamin E and Quercetin on Colistin Induced Nephrotoxicity in Adult Male Albino Rats

Mohamed Zaeim Hafez Ahmed1*, Ahmedel-Sayed Nour El-Deen1, Ahmad Gadalla1, Elsayed Elagamy Elsayed Mohamed2, Ramadan Hassan Ibrahim Thabet2, Ahmed Mohamed Gad Allah3, Ahmed Abdrabo Elshenawy Elsisi2, Ahmed Abdel Nasser Ahmed Mohamed2, Reda Mohamed Abdrabbou Fayyad2, Ayman Sabry Yassin Al Sayed4, Mohamed Nabil Mohamed4, Mohammed Zain-Alabedeen Abdelkareem4, Rafik Elsayed Aboelhythim Ereba2 and Muhammad Abdelbaeth Hassan Elfiky1

1Physiology Department, Faculty of Medicine, Al Azhar University, Egypt
2Phyarmacology Department, Faculty of Medicine, Al Azhar University, Egypt
3Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Al Azhar University, Egypt
4Microbiology Department, Faculty of Medicine, Al Azhar University, Egypt
*Corresponding Author: Mohamed Zaeim Hafez Ahmed, Physiology Department, Faculty of Medicine, Al Azhar University, Egypt.
Received: August 25, 2020; Published: October 01, 2020



Background: Colistin is one of the few remaining therapeutic options available for the treatment of infections caused by multidrug-resistant gram-negative bacteria. Notwithstanding its efficiency, nephrotoxicity is the major adverse effect that impedes the ability to administer high doses of colistin. Renal toxicity due to colistin was reported to be mainly present as acute tubular necrosis.

Objective: To evaluate that quercetin and vitamin E would show a protective effect against nephrotoxicity induced by colistin due to renoprotective effects.

Patient and Method: Fifty-six adult male albino rats of local strain weighing 150 ± 20g were purchased from the animal house of Assiut university. We measured kidney function tests and determination of oxidative stress biomarkers in renal tissues.

Results: There were significant differences among studied groups regarding creatinine, urinary GGT, BUN and MDA (p < 0.05). Also, colistin administration caused an increase in serum creatinine, urinary GGT, MDA, urea, and blood urea nitrogen (BUN) level versus the control group.

Conclusion: Based on reviewed studies, stress oxidative beside activating inflammatory and apoptotic pathways are the main mechanism of colistin nephrotoxicity. Quercetin and vitamin E could attenuate colistin-induced nephrotoxicity by decreasing oxidative stress and inflammation and increasing antioxidants.

 Keywords: Colistin; Nephrotoxicity; Quercetin; Vitamin E

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Mohamed Zaeim Hafez Ahmed., et al. “Protective Effect of Vitamin E and Quercetin on Colistin Induced Nephrotoxicity in Adult Male Albino Rats” ”. EC Pharmacology and Toxicology  11.6 (2023): 01-13.

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