EC Pharmacology and Toxicology

Smoking cessation is challenging due to withdrawal symptoms. Herbal remedies can help with their stress-relieving and anti-inflammatory properties. This study aimed to create gummies with herbal extracts to support quitting smoking. Extracts from tragacanth prepared. These extracts was mixed with honey, cinnamon oil, Vernonia cinerea to form gummies. The gummies were then tested for quality and sensory properties. The gummies were greenish, uniform in shape and size, with a pleasant aroma and chewy texture. They had a slightly acidic pH, ensuring stability. The taste was balanced and sweet, with a strong cardamom flavor. The weight of individual gummies was consistent. The herbal gummies showed good physical and sensory qualities, making them a potential aid for smoking cessation. They can help reduce withdrawal symptoms and support overall well-being, offering a natural and enjoyable option to assist in quitting smoking.

 Keywords: Nicotine Free; Medicated Gummies; Herbal; Potential Aid

1. Benowitz NL. “Nicotine addiction”. Primary Care: Clinics in Office Practice3 (1999): 611-631.
2. Döring N and Bortz J. “Forschungs method and Evaluation in den Sozial- und Humanwissenschaften”. Springer Lehrbuch. Berlin, Heidelberg: Springer Berlin Heidelberg (2016).
3. Graul AI and Prous J. “Executive summary: nicotine addiction”. Drugs of Today 6 (2005): 419-425.
4. Mahajan SD., et al. “Multifactorial etiology of adolescent nicotine addiction: a review of the neurobiology of nicotine addiction and its implications for smoking cessation pharmacotherapy”. Frontiers in Public Health 9 (2021): 664748.
5. Ren M and Lotfipour S. “Nicotine gateway effects on adolescent substance use”. The Western Journal of Emergency Medicine 5 (2019): 696-709.
6. Yuan M., et al. “Nicotine and the adolescent brain”. The Journal of Physiology16 (2015): 3397-3412.
7. David JK Balfour and Munafò MR. “The neurobiology and genetics of nicotine and tobacco”. Springer (2015).
8. Giulietti F., et al. “Pharmacological approach to smoking cessation: an updated review for daily clinical practice”. High Blood Pressure and Cardiovascular Prevention5 (2020): 349-362.
9. Pearson JL and Smiley SL. “E-cigarettes, harm reduction, and smoking cessation: where are we now?” Nicotine and Tobacco Research7 (2022): 943-944.
10. Teixeira-Lemos E., et al. “Development and characterization of healthy gummy jellies containing natural fruits”. Open Agriculture1 (2021): 466-478.
11. Parkash J., et al. “Herbs as traditional medicines: a review”. Journal of Drug Delivery and Therapeutics 5 (2018): 146-150.
12. Che CT., et al. “Herb-herb combination for therapeutic enhancement and advancement: theory, practice and future perspectives”. Molecules5 (2013): 5125-5141.
13. Chandrasekhar K., et al. “A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults”. Indian Journal of Psychological Medicine3 (2012): 255-262.
14. Armanini D., et al. “Licorice consumption and serum testosterone in healthy man”. Experimental and Clinical Endocrinology and Diabetes 6 (2002): 341-343.
15. Ranasinghe P., et al. “Medicinal properties of ‘true’ cinnamon (Cinnamomum zeylanicum): a systematic review”. BMC Complementary and Alternative Medicine1 (2013): 275.