EC Pharmacology and Toxicology

Review Article Volume 11 Issue 2 - 2023

Pharmacological Significance of Marine Seaweed, Halimeda opuntia

Md. Ariful Amin1, Tamim Ahsan1,2, Uzzal Chondra1, Jonia Akter1 and Md. Morshedul Alam1*

1Marine Biotechnology Laboratory, Department of Genetic Engineering and Biotechnology, Bangabandhu Sheikh Mujibur Rahman Maritime University, Mirpur 12, Dhaka, Bangladesh
2National Institute of Biotechnology, Savar, Dhaka, Bangladesh

*Corresponding Author: Md. Morshedul Alam, Marine Biotechnology Laboratory, Department of Genetic Engineering and Biotechnology, Bangabandhu Sheikh Mujibur Rahman Maritime University, Mirpur 12, Dhaka, Bangladesh.
Received: December 29, 2022; Published: January 30, 2023



Nowadays, looking for alternative medicine sources is a hot topic because they are readily available, safe, and, more particularly, come from sustainable sources. Seaweed-based medications are generated in numerous pharmaceutical and biotechnology businesses. Green algae known as Halimeda opuntia are particularly prevalent in tropical and subtropical coastal waters that are 1 - 2 meters deep. Numerous research point to this species as a key source of bioactivities and bioactive chemicals, both of which could serve as potential therapeutic targets in the pharmaceutical sector. Based on this hypothesis, a literature review that focused on the pharmacological significance of the seaweed Halimeda opuntia was conducted. Here, we report some of the species' drug-targeting effects, including its anticancer, antioxidant, cytotoxic, hypoglycemic, and antibacterial capabilities. This literature review will compel researchers to focus on this species in order to create new medications for human welfare.

Keywords: Halimeda opuntia; Green Seaweed; Pharmacology; Medicinal Value; Sustainable Drug Development; Bioactive Compounds

  1. Gupta V., et al. “Seaweed metabolomics: A new facet of functional genomics”. Advances in Botanical Research (2014): 31-52.
  2. Salehi B., et al. “Current trends on seaweeds: Looking at chemical composition, phytopharmacology, and cosmetic applications”. Molecules (2019): 4128.
  3. Kasanah N., et al. “Review antibacterial compounds from red seaweeds (Rhodophyta)”. Indonesian Journal of Chemistry2 (2015): 201-209.
  4. Manach C., et al. “Polyphenols: Food sources and bioavailability”. The American Journal of Clinical Nutrition (2004).
  5. Cherry P., et al. “Risks and benefits of consuming edible seaweeds”. Nutrition Reviews (2019).
  6. MacArtain P., et al. “Nutritional value of edible seaweeds”. Nutrition Reviews12 (2007): 535-543.
  7. Smitha JL., et al. “Nutrient and heavy metal content of edible seaweeds in New Zealand”. New Zealand Journal of Crop and Horticultural Science 38 (2010): 19-28.
  8. Brown EM., et al. “Seaweed and human health”. Nutrition Reviews 72 (2014): 205-216.
  9. Desideri D., et al. “Essential and toxic elements in seaweeds for human consumption”. Journal of Toxicology and Environmental Health 79 (2016): 112-122.
  10. Mohamed S., et al. “Seaweeds: A sustainable functional food for complementary and alternative therapy”. Trends in Food Science and Technology 23 (2012): 83-96.
  11. Chengkui Z., et al. “Chinese seaweeds in herbal medicine”. Hydrobiologia117 (1984): 152-154.
  12. De Jesus Raposo MF., et al. “Emergent sources of prebiotics: Seaweeds and microalgae”. Marine Drugs (2016).
  13. Wang X., et al. “Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression”. Cell Research (2019).
  14. Ahsan T. et al. “Phytochemical screening and evaluation of antioxidant and cytotoxic activities of Halimeda opuntia”. Journal of Marine Biology and Aquaculture1 (2020): 1-6.
  15. Islam T., et al. “Bioactive Compounds Screening and In Vitro Appraisal of Potential Antioxidant and Cytotoxicity of Cladophoropsis Isolated from the Bay of Bengal”. EC Pharmacology and Toxicology 8.10 (2020): 19-31.
  16. Islam T., et al. “Pharmacological prospects of Cladophoropsis seaweed”. Journal of Earth and Ocean Science 1.1 (2021): 9-24.
  17. Alam MM. “Prospect of marine bioactive peptides as DPP4 inhibitor”. Oceanography and Fisheries Open access Journal (OFOAJ)5 (2022): 555896.
  18. Amin MA., et al. “Green seaweed Ulva lactuca, a potential source of bioactive peptides revealed by in silico analysis”. Informatics in Medicine Unlocked 33 (2022): 101099.
  19. Akter J. et al. “Pharmacological importance of Gracilariopsis lemaniformis seaweed”. Journal of Rangamati Science and Technology University1 (2022).
  20. Alam MM. “Therapeutic potential of marine bioactive compounds against SARS-CoV2 infection”. CPQ Medicine1 (2020): 1-18.
  21. Davis GDJ., et al. “Seaweed metabolite database (SWMD): A database of natural compounds from marine algae”. Bioinformation 5 (2011): 361-364.
  22. Drew E. “Halimeda”. Encyclopedia of Modern Coral Reefs (2011): 535-539.
  23. Borowitzka MA., et al. “Calcification in the Green Alga Halimeda”. Journal of Experimental Botany5 (1976): 879-893.
  24. Hillis-Colinvaux L. “Ecology and taxonomy of Halimeda: primary producer of coral reefs”. Advances in Marine Biology 17 (1980): 0120261170.
  25. Guiry MD. “AlgaeBase”. World-wide electronic publication, National University of Ireland, Galway (2020).
  26. Paul VJ., et al. “Isolation of Halimedatrial: Chemical Defense Adaptation in the Calcareous Reef-Building Alga Halimeda”. Science4612 (1983): 747-749.
  27. Paul VJ., et al. “Use of ingested algal diterpenoids by Elysia halimedae Macnae (Opisthobranchia: Ascoglossa) as antipredator defenses”. The Journal of Experimental Marine Biology and Ecology 119 (1988): 15-29.
  28. Dini I., et al. “Alkaloid Caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with beta-sitosterol from the Halimeda cylindracea Decaisne”. Sains Malaysiana9 (2021): 2663-2674.
  29. Nazarudin MF., et al. “Metabolic variations in seaweed, Sargassum polycystum samples subjected to different drying methods via 1H NMR-based metabolomics and their bioactivity in diverse solvent extracts”. The Arabian Journal of Chemistry11 (2020): 7652-7664.
  30. Mujeeb F., et al. “Phytochemical evaluation, antimicrobial activity, and determination of bioactive components from leaves of Aegle marmelos”. BioMed Research International 2014 (2014): 1-11.
  31. Venkataraman B., et al. “Antibacterial, antioxidant activity and GC-MS analysis of Eupatorium odoratum”. Asian Journal of Pharmaceutical and Clinical Research2 (2012): 99-106.
  32. Esghaei M., et al. “Evaluation of anticancer activity of Camellia sinensis in the caco-2 colorectal cancer cell line”. Asian Pacific Journal of Cancer Prevention6 (2018): 1697-1701.
  33. Elia J., et al. “4-cholesten-3-one decreases breast cancer cell viability and alters membrane raft-localized EGFR expression by reducing lipogenesis and enhancing LXR-dependent cholesterol transporters”. Lipids in Health and Disease168 (2019): 1-15.
  34. Nazarudin MF., et al. “Chemical composition and evaluation of the α-glucosidase inhibitory and cytotoxic properties of marine algae Ulva intestinalis, Halimeda macroloba, and Sargassum ilicifolium”. Evidence-Based Complementary and Alternative Medicine 2020 (2020): 1-13.
  35. Ravi L., et al. “Cytotoxic potential of N-hexadecanoic acid extracted from Kigelia pinnata Leaves”. The Asian Journal of Cell Biology1 (2017): 20-27.
  36. Kubo I., et al. “Antibacterial activity of long-chain alcohols: the role of hydrophobic alkyl groups”. Bioorganic and Medicinal Chemistry Letters6 (1993): 1305-1308.
  37. Ozdemir G., et al. “Antibacterial activity of volatile extracts of Spirulina plantensis”. Phytotherapy Research 18 (2004): 754-757.
  38. Saad-Allah K., et al. “Protective Role of the Seaweed Halimeda opuntia Extract on Cadmium-Stressed Eruca sativa (Mill.)”. Egyptian Journal of Botany3 (2006): 863-881.
  39. Premarathna AD. et al. “Preliminary screening of the aqueous extracts of twenty-three different seaweed species in Sri Lanka with in-vitro and in-vivo assays”. Heliyon6 (2020): e03918.
  40. De Oliveira e Silva AM., et al. “In vivo and in vitro antioxidant activity and hepatoprotective properties of polyphenols from Halimeda opuntia (Linnaeus) Lamouroux”. Redox Report2 (2012): 47-53.
  41. Hamza AH., et al. “Potential Antimicrobial, Antioxidant and Anityrosenase Activities achieved by Selected Species of Marine Macroalgae”. Journal of Pure and Applied Microbiology 8 (2014): 257-265.
  42. Gazali M., et al. “The Screening of Green Algae Halimeda opuntia (Linnaeus) as an Antioxidant from the Coast of West Aceh”. Jurnal Ilmu Pertanian Indonesia3 (2019): 267-272.
  43. Vidal A., et al. “Antioxidant activity and polyphenols of seaweed species Halimeda opuntia and Halimeda monile”. ARS Pharmaceutica 50 (2009): 24-31.
  44. Zuo AR., et al. “The antityrosinase and antioxidant activities of flavonoids dominated by the number and location of phenolic hydroxyl groups”. Chinese Medicine1 (2018) 51.
  45. Nufus C., et al. “Characteristics of green seaweed salt as alternative salt for hypertensive patients”. IOP Conference Series: Earth and Environmental Science1 (2019): 012050.
  46. Selim SA. “Antimicrobial, Antiplasmid and Cytotoxicity Potentials of Marine Algae Halimeda opuntia and Sarconema filiforme collected from Red Sea Coast”. International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering1 (2012): 79-84.
  47. Tillekeratne LMV., et al. “4,9-diacetoxyudoteal: A linear diterpene aldehyde from the green alga Halimeda opuntia”. Phytochemistry6 (1084) 1331-1333.
  48. Nakano T., et al. “In vitro promoting activity of human interferon β production by extracts of marine algae from Japan”. Cytotechnology1-3 (1997): 239-241.
  49. Mishra JK., et al. “Antibacterial Activity of Seaweed Halimeda opuntia From the Coasts of Souths Andaman”. Global Journal of Bio-Science and Biotechnology3 (2016): 345-348.
  50. Hendri MH. “Antibacterial Potential Screening of Halimeda sp on Some Types of Pathogenic Bacteria”. International Journal of Marine Science 53 (2015): 1-6.
  51. Al-Judaibi A. “Antibacterial Effects of Extracts of Two Types of Red Sea Algae”. Journal of Biosciences and Medicines2 (2014): 74-82.
  52. Mtolera MS., et al. “Antimicrobial activity of extracts from six green algae from Tanzania”. Current Trends in Marine Botanical research In East African Region (1996): 211-217.
  53. Ballantine DL., et al. “Antibiotic activity of lipid-soluble extracts from Caribbean marine algae”. Twelfth International Seaweed Symposium”. Dordrecht: Springer Netherlands (1987): 463-469.
  54. Gupta M., et al. “Antimicrobial Activity of Various Algae of the Panamanian Atlantic Coast”. Revista Médica de Panamá1 (1991): 64-68.
  55. Engel S., et al. “Antimicrobial activities of extracts from tropical Atlantic marine plants against marine pathogens and saprophytes”. Marine Biology5 (2006): 991-1002.
  56. Anggadiredja JT. “Diversity of Antibacterial Compounds from Eucheuma Serra, Halimeda Opuntia”. Jurnal Teknologi Lingkungan2 (2011): 131-142.
  57. Ahmed AE., et al. “Diversity of Toxigenic Molds and Mycotoxins Isolated from Dairy Products: Antifungal Activity of Egyptian Marine Algae on Aspergillus and Candida Species”. Journal of Pure and Applied Microbiology1 (2020): 215-232.
  58. Soares AR., et al. “Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus”. Revista Brasileira de Farmacognosia4 (2012): 714-723.
  59. Parra MG., et al. “Actividad antileishmanial de seis extractos de organismos marinos”. Revista Cubana de Medicina tropical1 (2012): 61-64.
  60. Yanuhar U., et al. “The effect of crude protein Halimeda On Cyprinus carpio infected Koi Harpes Virus on expression of major histocompatibility complex class-1”. Journal of Fisheries and Marine Research 1.1 (2017): 15-19.
  61. Kuyucak N., et al. “Accumulation of Cobalt by Marine Alga”. Biotechnology and Bioengineering 33 (1989): 809-814.
  62. Volesky B. “Advances in biosorption of metals: Selection of biomass types” FEMS Microbiology Reviews 14 (1994): 291-302.
  63. Mutia G., et al. “Analysis of Bio-Accumulation of Heavy Metals in Seaweeds Ulva rigida and Halimeda opuntia in Validation of Their Safety for Use in Aquaculture Feeds in Kenya”. IOSR Journal of Environmental Science, Toxicology and Food Technology8 (2018): 56-63.
  64. Nessim A., et al. “Mitigation of Lead Stress in Triticum aestivum by Seed Priming in Aqueous Extracts of The Macroalgea Halimeda opuntia and Codium fragile”. Egyptian Journal of Botany2 (2018): 263-274.
  65. Udayangani RMAC., et al. “Potential Health Benefits of Sulfated Polysaccharides from Marine Algae”. Encyclopedia of Marine Biotechnology (2020): 629-635.
  66. Chowdhury KR., et al. “Pharmaceutical potential of endophytes associated to marine sponge and algae from the Bay of Bengal and their contribution to the blue economy of Bangladesh”. International Journal of Pharmaceutical Sciences and Research5 (2022): 2013-2019.
  67. Hawas UW., et al. “Bioactive anthraquinones from endophytic fungus Aspergillus versicolor isolated from red sea algae”. Archives of Pharmacal Research10 (2012): 1749-1756.
  68. Basondwah SH., et al. “Epiphytic Bacteria Associated with the Green Algal Halimeda Opuntia as a Source of Antibacterial Agent”. IOSR Journal of Pharmacy and Biological Sciences3 (2019): 79-85.
  69. Alam MM. “Essence of antioxidants in aging science: NRF2, a true fact”. CPQ Medicine5 (2019): 1-5.
  70. Nazarudin MF., et al. “Preliminary screening of antioxidant and cytotoxic potential of green seaweed, Halimeda opuntia (Linnaeus) Lamouroux”. Saudi Journal of Biological Sciences4 (2022): 2698-2705.
  71. Goto M., et al. “Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis”. Genes to Cells 20 (2015): 464-480.
  72. Alam MM., et al. “Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2”. Journal of Biological Chemistry18 (2017): 7519-7530.
  73. Okazaki K., et al. “Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers”. Nature Communications 11 (2020): 5911.
  74. Elia J., et al. “4-cholesten-3-one decreases breast cancer cell viability and alters membrane raft-localized EGFR expression by reducing lipogenesis and enhancing LXR-dependent cholesterol transporters”. Lipids in Health and Disease168 (2019): 1-15.
  75. Yoshie Y., et al. “Compositional difference of phenolic compounds between two seaweeds, Halimeda spp”. Journal of the Tokyo University of Fisheries 88 (2002): 21-24.
  76. Alwaleed EA., et al. “Evaluation of the pancreatopreotective effect of algal extracts on alloxan-induced diabetic rat”. Bioactive Carbohydrates and Dietary Fibre 24 (2020): 100237.

Md. Morshedul Alam.,et al. Pharmacological Significance of Marine Seaweed, Halimeda opuntia. EC Pharmacology and Toxicology 11.2 (2023): 51-63.