EC Pharmacology and Toxicology

In eukaryotic cells, mitochondria serve as the energy power-house. Through proper electron transport chain to get ATP, and mitochondrial membrane potential (MMP) are the common manifestation of mitochondrial functions. Mitochondria are also regarded as the redox reaction cellular organelle. NRF2-KEAP1 system acts as the major redox homeostatic system in the biological environment. In some studies, it was observed that impaired NRF2-KEAP1 system reduces mitochondrial function but the underlying mechanism was not well studied. Alam., et al. (2023), in their recent study proved that NRF2 regulates the supersulfide species generation by increasing the availability of cysteine and its further metabolism directly modulates the mitochondrial function, which has been focused here.

 Keywords: Supersulfide Species; NRF2; KEAP1; Mitochondrial Membrane Potential; SQOR; CARS2

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