EC Pharmacology and Toxicology

Research Article Volume 11 Issue 3 - 2023

Metabolic Syndrome Predictors and Cancer Incidence against the Backdrop of a Rising Gradient in the Burden of Alcoholism in Men in 160 Countries 2004

Ludmila Radkevich1* and Dariya Radkevich2

1Doctor of Biological Sciences, Chief Researcher, Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences CTP PCP RAS, Moscow, Russia
2Specialist (Physicist), Analyst, Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences CTP PCP RAS, Moscow, Russia

*Corresponding Author: Ludmila Radkevich, Doctor of Biological Sciences, Chief Researcher, Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences CTP PCP RAS, Moscow, Russia.
Received: May 18, 2022; Published: February 09, 2023



Objective: To study the risk factors for the burden of cancer and predictors of the metabolic syndrome against the background of the gradient of alcoholism in 160 countries of the world 2004.

Materials and Methods: For the purposes of the study, a database of 160 countries on the burden of alcoholism, 14 types of cancer (ICD-10 codes) and 8 predictors of metabolic syndrome were created. Burden of disease (DALY) data for men in 160 countries, standardized by sex and age, were selected from the 2004 GBD database. The U-Mann-Whitney-Wilcoxon test was used for data analysis.

Results: The study found a statistically significant 23-fold increase in the burden of alcoholism across 8 groups in 160 countries. Burden of 9 types of cancer (a - Trachea, bronchus, lung cancers, Stomach cancer and Colon and rectum cancers; b - Prostate cancer, Leukaemia and Pancreas cancer; c - Oesophagus cancer, Melanoma and other skin cancers, and Breast cancer) in 8 groups of countries increased by 1.5 - 3 times in parallel with the growth of the alcoholism gradient, the increase in the consumption of strong alcohol, cigarettes and animal products. The burden of 5 types of cancer (d - Liver cancer, Lymphomas, multiple myeloma, Mouth and oropharynx cancers, Bladder cancer and other neoplasms) decreased by 3 - 4 times as the alcoholism gradient increased and was associated with viral infections. In parallel with the growth of the alcoholism gradient in countries, the characteristics of 8 types of metabolic syndrome predictors increased by 1.5 - 3 times: overweight and obesity (BMI ≥ 25 and 30 kg/m2), hyperlipidemia (≥ 5 and 6.2 mmol/L), hyperglycemia (≥ 7 mmol/L), blood pressure (≥ 140/90 mm Hg, without pharmacological correction and with correction) and low physical activity (≤ 60 min/day). The life expectancy of men was not statistically significantly different at the minimum and maximum burden of alcoholism.

However, the gender difference in life expectancy between men and women increased statistically significantly from 1st group of countries to 8th group of countries from 3 to 7 years. This was indicative of the loss of male LE as the alcoholism gradient increased.

Conclusion: The results show an increase in risk factors for the burden of 9 types of cancer and 8 types of predictors of metabolic syndrome in parallel with the increase in the alcoholism gradient in 180 countries.

Keywords: Alcoholism Gradient; Burden of 14 Types of Cancer; 8 Predictors of Metabolic Syndrome; Levels of Alcohol; Tobacco; Food Consumption; The Quality of Life

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Ludmila Radkevich and Dariya Radkevich. Metabolic Syndrome Predictors and Cancer Incidence against the Backdrop of a Rising Gradient in the Burden of Alcoholism in Men in 160 Countries 2004. EC Pharmacology and Toxicology 11.3 (2023): 28-58.

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