EC Pharmacology and Toxicology

In the field of chemical and pharmaceutical analysis, hyphenated techniques range from the combinations involving separation-separation, separation-identification and identification-identification techniques and are widely used nowadays, as they hold many advantages like fast accurate analysis, a higher degree of automation, higher sample throughput, better reproducibility, specificity and sensitivity. They also reduce contamination due to closed systems and offer simultaneous separation and quantification, leading to better analysis.

In the past decade, their use has increased manifold and therefore, it is thought imperative to briefly discuss the latest progress in this field . In the present article, an attempt has been made to briefly mention some information on various hyphenated techniques like LC-MS (Liquid Chromatography-Mass Spectroscopy), GC-MS (Gas Chromatography-Mass Spectroscopy), LC-IR (Liquid Chromatography-Infra-Red Spectroscopy), as well as, LC-MS-MS (Liquid Chromatography-Mass Spectroscopy-Mass Spectroscopy), LC-NMR-MS (Liquid Chromatography-Nuclear Magnetic Resonance-Mass Spectroscopy), etc.

Keywords: Hyphenated Analytical Techniques; Analytical Chemistry

1. Hirschfeld T. “The hyphenated methods”. Analytical Chemistry 2 (1980): 297 A-312.
2. Jain KS., et al. “A Review on Hyphenated Analytical Techniques”. Current Analytical Chemistry 18 (2022): 956-976.
3. Jain KS., et al. “Hyphenated techniques in analytical world”. Indian Journal of Pharmaceutical Education and Research 4 (2008): 393-401.
4. Patel KN., et al. “Hyphenated techniques and their applications in Pharmacy”. Pharmaceutical Methods 1 (2010): 1-13.
5. Joshi RR., et al. “Hyphenated technique- a boon to analytical world”. International Journal of Pharmacy and Pharmaceutical Sciences 11 (2022): 4184-4191.
6. Nagajyothi S., et al. “Hyphenated techniques- A comprehensive review”. International Journal of Advanced Research and Development 4 (2017): 63-71.
7. Meena PL., et al. “A review of singular and hyphenated analytical techniques in trace element analysis”. Chemistry Research Journal 1 (2019): 117-124.