EC Pharmacology and Toxicology

Naringin, a natural bioflavonoid known for its therapeutic potential, faces problems in clinical use due to its low solubility. To address this, a topical gel was developed by using solid dispersions aimed at increasing both solubility and effectiveness. This was prepared using the kneading method and evaluated. Among the various formulations tested, F4 showed the highest drug release (98.6%), making it the most promising candidate. This optimized dispersion was then incorporated into a topical gel and evaluated. The final gel formulation (X5) exhibited a pH of 5.5, high drug content (98.6%), and a controlled release profile. Stability studies conducted over a period of 30 and 90 days, which demonstrated consistent physicochemical properties, with no observable changes in pH, drug content. These indicate that the developed solid dispersion gel has enhanced solubility and therapeutic use, offering an approach for topical drug delivery with the potential to improve patient adherence and clinical efficacy.

 Keywords: Naringin; Solubility; Kneading; Efficacy; Stability; In Vitro Studies

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