EC Pharmacology and Toxicology

Opinion Volume 11 Issue 4 - 2023

Current Hormone Treatments to Improve Sleep Problems in Menopause

Marisa Cabeza*

Department of Biological Systems, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso, Colonia Villa Quietud, CP, Ciudad de México, México

*Corresponding Author: Marisa Cabeza, Department of Biological Systems, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso, Colonia Villa Quietud, CP, Ciudad de México, México.
Received: February 06, 2023; Published: March 13, 2023



Menopause marks the cessation of menstruation due to the loss of follicular function [1,2]. Some women in this stage report several symptoms that prevent them from reaching deep sleep, reducing their quality of life, and triggering a depressive state, lousy mood, and memory loss [3-5]. It has been previously reported that such sleep disorders worsen with age; 9.2% of women between 40 - 49 years, 21.1% between 50 - 59 years, and 25.7% > of 60 years suffer from them [2,5].

During the late menopausal transition in women, annual hormone testing indicates a decrease in estradiol and an increase in follicle-stimulating hormone (FSH) [1]. The rise in FSH levels has been positively associated with sleeplessness, measured by polysomnography. The polysomnography [6] process has been useful in determining and defining the arousals in perimenopausal women after sleep onset [7]. Lowering FSH levels with estrogen and progesterone treatment (EPT) may be an option to decrease the arousals after sleep onset and the number of awakenings in women who report this sleep problem [8]. It has been demonstrated that estrogen therapy improves sleeping problems in postmenopausal women [2,8]. Moreover, Plamberger., et al. showed, in women, that both progestogen treatment and the luteal phase of the menstrual cycle increase fast sleep spindle density.