EC Ophthalmology

Research Article Volume 17 Issue 6 - 2026

Thrombophilia in Pregnant Women with Gestational Arterial Hypertension and Retinal Vascular Pathology

Tatyana Vasilyevna Shelkovnikova1*, Sibirskaya EV2,3,4, Urazova OI5, Katsadze Yu L6, Kapustin SI7, Nikiforova PO2,4, Vavin GV1, Shchigareva SO1 and Polennikova ES8

1Kuzbass Regional Clinical Hospital Named After S.V. Belyaev, Kemerovo, Russia
2Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia
3Department of Obstetrics, Gynecology and Reproductive Medicine, Russian University of Medicine, Moscow, Russia
4Pirogov Russian National Research Medical University Children’s Clinical Hospital, Ministry of Health of Russia, Moscow, Russia
5Siberian State Medical University, Tomsk, Russia
6Russian Research Institute of Hematology and Transfusiology, Federal Medical-Biological Agency, St. Petersburg, Russia
7Virological Center of St. Petersburg State Healthcare Institution “Clinical Hospital, № 31, St. Petersburg, Russia
8Laser Optic Medical Clinic LLC, Kemerovo, Russia

*Corresponding Author: atyana Vasilyevna Shelkovnikova, Kuzbass Regional Clinical Hospital Named After S.V. Belyaev, Kemerovo, Russia.
Received: February 26, 2026; Published: September 24, 2026



Research Aim: To study parameters of the hemostatic system, plasma lupus anticoagulant (LA) levels, and hemostasis gene polymorphisms in pregnant women with gestational arterial hypertension (GAH) and retinal vascular pathology.

Materials and Methods: The study included 50 pregnant women aged 22÷37 years at 8÷38 weeks of gestation. Standard and specialized ophthalmological examination methods were used. Hemostasis system studies were performed using screening and specialized methods. Molecular genetic testing was conducted via PCR.

Results and Conclusion: MIT was found in 100% of pregnant women with FPI, GAH, and retinal vascular pathology; LA was present in 16%.

Keywords: Hemostasis System; Pregnant Women; Thrombophilia; LA; Endothelial Dysfunction

  1. Shelkovnikova TV., et al. “Ophthalmologic monitoring of thrombophilia in pregnant women”. EC Ophthalmology12 (2019): 01.
  2. Shelkovnikova TV., et al. “Clinical and laboratory changes in the hemostasis system in pregnant women with pvhd. Indications for retinal laser photocoagulation”. Proliferative syndrome in biology and medicine Materials II of the Russian Forum with international participation, Moscow, (In Russ.) (2022).
  3. Kolenko OV and Sorokin EL. “A study of the possible causal relationship between the formation of acute vascular pathology of the eye in women and the transferred OPG-gestosis”. Bulletin SO RAMN 4 (2009): 85-87.
  4. Kolenko OV., et al. “The probable reasons of vascular disorders in women of childbearing age”. Dal’nevostochnyj Medicinskij Zhurnal 1 (2011): 65-67.

Tatyana Vasilyevna Shelkovnikova., et al. “Thrombophilia in Pregnant Women with Gestational Arterial Hypertension and Reti- nal Vascular Pathology”. EC Ophthalmology 17.9 (2026): 01-03.