EC Ophthalmology

New technologies in ophthalmomicrosurgery in developed countries have led to a change in the epidemiology of sympathetic ophthalmia (SO) and vitreoretinal surgery on damaged eyes is becoming a risk factor. At the present stage of the 21^st century, SO is not disappearing disease, its frequency remains at the level of the end of the twentieth century, amounting to 0.3 - 0.9% in adults and 0.24% in children. The authors draw attention to the modern understanding of SO as a multifactorial autoimmune disease. The clinical features of the frequent occurrence of sympathetic panuveitis, the difficulties of diagnosis and the need to use multimodal imaging - OCT, A-OCT, FFA and B-scan ultrasonography.

 Keywords: Sympathetic Ophthalmia; Vitreoretinal Surgery; Multifactorial Autoimmune Disease

1. Arkhipova LT. “Sympathetic ophthalmia (pathogenesis, pathomorphology, clinic, diagnosis, treatment and prevention)”. M (2006): 247.
2. Arkhipova LT. “Phenotype of the ABO blood group in sympathetic ophthalmia”. Russian Ophthalmological Journal 1 (2012): 12-17.
3. Arkhipova LT. “On the frequency of sympathetic ophthalmia. Myth and reality”. Russian Ophthalmological Journal 3 (2016): 95-100.
4. Arkhipova LT and Filatova IA. “Prevention of sympathetic ophthalmia: enucleation or evisceration?” Russian Ophthalmological Journal4 (2017): 97-103.
5. Arkhipova LT and Arkhipova MM. “Sympathetic ophthalmia at the present stage of the XXI century. Question and Answer”. Moscow (2024): 103.
6. Rao NA., et al. “The role of the penetrating wound in the development of sympathetic ophthalmia”. Archives of Ophthalmology 1 (1983): 102-104.
7. Chan CC and Mochiziki M. “Sympathetic ophthalmia: autoimmunе ocular inflammatory disease”. Seminars in Immunopathology 2 (1999): 125-134.
8. Xi K Chu and Chan CC. “Sympathetic ophthalmia to the twenty-first century and beyond”. Journal of Ophthalmic Inflammation and Infection 1 (2013): 49-61.
9. Arkhipova LT. “Sympathetic ophthalmia after operative eye surgery”. Clinical Ophthalmology 1 (2004): 51-58.
10. Kilmartin DJ., et al. “Sympathetic ophthalmia risk following vitrectomy: should we counsel patients?”. British Journal of Ophthalmology 5 (2000): 448-449.
11. Arkhipova LT. “Repeated traumas and repeated operation are risk factors of sympathetic ophthalmia”. In Proceedings of the XI Congress of the European Ophthalmological Society. Hungary. Budapest (1997).
12. Su DH and Chee SP. “Sympathetic ophthalmia in Singapore: new trend in an old disease”. Graefe's Archive for Clinical and Experimental Ophthalmology 2 (2006): 243-247.
13. Drozdova EA., et al. “Sympathetic ophthalmia following ocular trauma: peculiarities of disease progression as evidenced by Chelyabinsk region date”. Russian Ophthalmological Journal4 (2015): 21-25.
14. Kumar K., et al. “Sympathetic ophthalmia in pediatric age group: clinical features and challenges in management in a tertiary center in Southern India”. Ocular Immunology and Inflammation 5 (2014): 367-372.
15. Savar A., et al. “Enucleation for open globe injury”. American Journal of Ophthalmology 4 (2009): 595-600.
16. Paulbuddhe V., et al. “Sympathetic ophthalmia: Where do we currently stand on treatment strategies?”. Clinical Ophthalmology 15 (2021): 4201-4218.
17. Parchand S., et al. “Sympathetic ophthalmia: A comprehensive update”. Indian Journal of Ophthalmology 6 (2022): 1931-1944.
18. Hong Zhuang., et al. “Clinical classification, visual outcomes and optical coherence tomographic features of 48 patient with posterior sympathetic ophthalmia”. Orphanet Journal of Rare Diseases 1 (2022): 103.