EC Ophthalmology

Case Report Volume 11 Issue 12 - 2020

Is the Long-Term Use of Topical Carbonic Anhydrase Inhibitors and Beta-Blockers Necessary after Intraocular Lens Replacement Surgery?

Nicholas A Kerna1,2*, Uzoamaka Nwokorie3, Raymond Nomel4, Brenda N Ramirez Medina5, Onyeka Olisemeka6 and Lawrence U Akabike7

1SMC–Medical Research, Thailand
2First InterHealth Group, Thailand
3University of Washington, USA
4All Saints University, College of Medicine, St. Vincent and the Grenadines
5Department of Internal Medicine, Aventura Hospital and Medical Center, USA
6McMaster University, Canada
7Larrico Enterprises, LLC, USA

*Corresponding Author: Nicholas A Kerna, (mailing address) POB47 Phatphong, Suriwongse Road, Bangkok, Thailand 10500.
Contact: medpublab+drkerna@gmail.com.
Received: October 05, 2020; Published: November 25, 2020



Intraocular pressure (IOP) tends to increase during and after intraocular lens (IOL) replacement surgery, a common procedure for cataracts. There are varied risk factors in IOP-rise following IOL replacement surgery, including preoperative condition, devices, procedures, physician/surgeon-experience, anatomical variables, and pre-, peri-, and post-surgical drug applications. The most notable and effective prevention, management, and treatment method of post-surgical IOP-rise (and non-surgically-related glaucoma) is applying carbonic anhydrase inhibitors and beta-blockers. However, many physicians customarily continue to prescribe these medicines beyond their effective and necessary use. This prolonged prescribing might well protect the physician, guarding against the possibility of increased IOP post-surgically, but might cause the patient (or insurance company) unwarranted expense and adverse effects from the long-term prescription use in the absence of harmful IOP. These IOP-reducing drugs are efficacious; nevertheless, evidence-based research regarding any benefits of their prolonged application following IOL replacement surgical is limited.

Keywords: Cataract; Glaucoma; Intraocular Pressure; Intraocular Lens; Replacement Surgery

  1. Grzybowski A and Kanclerz P. “Early postoperative intraocular pressure elevation following cataract surgery”. Current Opinion in Ophthalmology 30.1 (2019): 56-62. 
  2. Levkovitch-Verbin H., et al. “Intraocular pressure elevation within the first 24 hours after cataract surgery in patients with glaucoma or exfoliation syndrome”. Ophthalmology 115.1 (2008): 104-108.
  3. Ahmed II., et al. “Revisiting early postoperative follow-up after phacoemulsification”. Journal of Cataract and Refractive Surgery 28.1 (2002): 100-108.
  4. Levkovitch-Verbin H., et al. “Intraocular pressure elevation within the first 24 hours after cataract surgery in patients with glaucoma or exfoliation syndrome”. Ophthalmology 115.1 (2008): 104-108.
  5. Tranos P., et al. “Postoperative intraocular pressure spikes: the need to treat”. Eye 18.7 (2004): 673-679.
  6. Bömer TG., et al. “Intraocular pressure rise after phacoemulsification with posterior chamber lens implantation: effect of prophylactic medication, wound closure, and surgeon’s experience”. British Journal of Ophthalmology 79.9 (1995): 809-813.
  7. Kim WJ., et al. “Effect of Preoperative Factor on Intraocular Pressure after Phacoemulsification in Primary Open-angle Glaucoma and Primary Angle-closure Glaucoma”. Korean Journal of Ophthalmology 33.4 (2019): 303-314.
  8. Slabaugh MA., et al. “Risk factors for acute postoperative intraocular pressure elevation after phacoemulsification in glaucoma patients”. Journal of Cataract and Refractive Surgery 40.4 (2014): 538-544.
  9. Elfersy AJ., et al. “IOP Elevation After Cataract Surgery: Results for Residents and Senior Staff at Henry Ford Health System”. Journal of Glaucoma 25.10 (2016): 802-806.
  10. Jarstad JS., et al. “Immediate Postoperative Intraocular Pressure Adjustment Reduces Risk of Cystoid Macular Edema after Uncomplicated Micro Incision Coaxial Phacoemulsification Cataract Surgery”. Korean Journal of Ophthalmology 31.1 (2017): 39-43.
  11. Bissen-Miyajima H. “Ophthalmic viscosurgical devices”. Current Opinion in Ophthalmology 19.1 (2008): 50-54.
  12. Kohnen T., et al. “Evaluation of intraocular pressure with Healon and Healon GV in sutureless cataract surgery with foldable lens implantation”. Journal of Cataract and Refractive Surgery 22.2 (1996): 227-237.
  13. O’Brien PD., et al. “Risk factors for a postoperative intraocular pressure spike after phacoemulsification”. The Canadian Journal of Ophthalmology 42.1 (2007): 51-55.
  14. Cho YK. “Early intraocular pressure and anterior chamber depth changes after phacoemulsification and intraocular lens implantation in nonglaucomatous eyes. Comparison of groups stratified by axial length”. Journal of Cataract and Refractive Surgery 34.7 (2008): 1104-1109.
  15. Kersey JP and Broadway DC. “Corticosteroid-induced glaucoma: a review of the literature”. Eye 20.4 (2006): 407-416.
  16. Bonnell LN., et al. “One-day postoperative intraocular pressure spikes after phacoemulsification cataract surgery in patients taking tamsulosin”. Journal of Cataract and Refractive Surgery 42.12 (2016): 1753-1758.
  17. Kasetti SR., et al. “Preventing intraocular pressure increase after phacoemulsification and the role of perioperative apraclonidine”. Journal of Cataract and Refractive Surgery 28.12 (2002): 2177-2180.
  18. Dayanir V., et al. “Medical control of intraocular pressure after phacoemulsification”. Journal of Cataract and Refractive Surgery 31.3 (2005): 484-488.
  19. Rainer G., et al. “Effect of dorzolamide and latanoprost on intraocular pressure after small incision cataract surgery”. Journal of Cataract and Refractive Surgery 12 (1999): 1624-1629.
  20. Ermis SS., et al. “Comparing the effects of travoprost and brinzolamide on intraocular pressure after phacoemulsification”. Eye 19.3 (2005): 303-307.
  21. Lai JS., et al. “Latanoprost versus timolol gel to prevent ocular hypertension after phacoemulsification and intraocular lens implantation”. Journal of Cataract and Refractive Surgery 26.3 (2000): 386-391.
  22. Rainer G., et al. “Effect of a fixed dorzolamide-timolol combination on intraocular pressure after small-incision cataract surgery with Viscoat”. Journal of Cataract and Refractive Surgery 29.9 (2003): 1748-1752.
  23. Georgakopoulos CD., et al. “Brinzolamide-timolol fixed combination for the prevention of intraocular pressure elevation after phacoemulsification”. Clinical and Experimental Ophthalmology 41.7 (2013): 662-667.
  24. Konstas AG., et al. “Comparison of 24-hour intraocular pressure reduction obtained with brinzolamide/timolol or brimonidine/ timolol fixed-combination adjunctive to travoprost therapy”. Journal of Ocular Pharmacology and Therapeutics 29.7 (2013): 652-657.
  25. Ornek K., et al. “Effect of 1% brinzolamide and 0.5% timolol fixed combination on intraocular pressure after cataract surgery with phacoemulsification”. International Journal of Ophthalmology 6.6 (2013): 851-854.
  26. Lee SY., et al. “Effect of chronic anti-glaucoma medications and trabeculectomy on tear osmolarity”. Eye 27.10 (2013): 1142-1150.
  27. Zhang X., et al. “Ocular Surface Disease and Glaucoma Medications: A Clinical Approach”. Eye Contact Lens 45.1 (2019): 11-18.

Nicholas A Kerna., et al. Is the Long-Term Use of Topical Carbonic Anhydrase Inhibitors and Beta-Blockers Necessary after Intraocular Lens Replacement Surgery?. EC Ophthalmology 11.12 (2020): 09-14.