EC Ophthalmology

Iris mammillations are a rare ocular disorder in which distinctive villiform protuberances can cover the entire iris surface or just a part of it. In most of the cases, they are unilateral and often sporadic.

They are seen usually in association with oculodermal melanosis, more often in highly pigmented ethnic groups than in Caucasians or Asians [1,2].

The main differential diagnosis of iris mammillations is Lisch nodules seen in neurofibromatosis type 1 [1-3].

We report a case of iris mammillations, which highlights that they can occur even without ocular melanocytosis or systemic diseases.

1. Ragge NK., et al. “Iris mammillations: significance and associations”. Eye1 (1996): 86-91.
2. Peyman M., et al. “Iris mammillations in two female siblings with congenital adrenal hyperplasia”. BMJ Case Reports (2010): bcr0820103266.
3. Sánchez Marugán B., et al. “Iris mammillations. Three case reports”. Archivos de la Sociedad Española de Oftalmología7 (2014): 279-281.