EC Ophthalmology

Research Article Volume 14 Issue 12 - 2023

Bilateral Nasal Ectopia Lentis and Major Depressive Disorder in Marfan Syndrome: A Case Report

Rajnish Raj1, Anuradha Raj2* and Vineeta Kumari3

1Professor and HOD, Department of Psychiatry, Government Medical College and Rajindra Hospital, Patiala, Punjab, India
2Additional Professor and HOD, Department of Ophthalmology, All India Institute of Medical Sciences, Bathinda, Punjab, India
3Junior Resident, Department of Ophthalmology, All India Institute of Medical Sciences, Bathinda, Punjab, India

*Corresponding Author: Rajnish Raj, Professor and HOD, Department of Psychiatry, Government Medical College and Rajindra Hospital, Patiala, Punjab, India.
Received: October 06, 2023; Published: November 17, 2023



Marfan syndrome is characterized by skeletal, cardiac, and ocular abnormalities leading to various presentations in the respective system. Depression can also be seen in this syndrome due to various factors such as unemployment, chronic pain, and cardiac problems. The most characteristic ocular feature is bitemporal ectopia lentis, high myopia, and retinal detachment. This case reports a patient with Marfan syndrome having bilateral nasal ectopia lentis, skeletal abnormalities, and mild depression.

Keywords: Depression; Marfan Syndrome; Nasal Ectopia Lentis

  1. Milewicz DM., et al. “Treatment of aortic disease in patients with Marfan syndrome”. Circulation 11 (2005): e150-e157.
  2. Dietz HC., et al. “Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene”. Nature (1991): 337-339.
  3. Montgomery SA., et al. “A new depression scale designed to be sensitive to change”. British Journal of Psychiatry (1979): 382-389.
  4. Guo X. “A clinical study and analysis of congenital lenticular dislocation”. Eye Science (1991): 185-189.
  5. De Paepe A., et al. “Revised diagnostic criteria for Marfan syndrome”. American Journal of Medical Genetics (1996): 417-426.
  6. Loeys BL., et al. “The revised Ghent nosology for the Marfan syndrome”. Journal of Medical Genetics (2010): 476-485.
  7. Hamod A., et al. “Presenting signs and clinical diagnosis in individuals referred to rule out Marfan syndrome”. Ophthalmic Genetics (2003): 35-39.
  8. Nistala H., et al. “Fibrillin-1 and −2 differentially modulate endogenous TGF-beta and BMP bioavailability during bone formation”. Journal of Cell Biology (2010): 1107-1121.
  9. Wood JR., et al. “Pulmonary disease in patients with Marfan syndrome”. Thorax (1984): 780-784.
  10. Murdoch JL., et al. “Life expectancy and causes of death in the Marfan syndrome”. The New England Journal of Medicine (1972): 804-808.
  11. Cross HE., et al. “Ocular manifestations in the Marfan syndrome and homocystinuria”. American Journal of Ophthalmology (1973): 405-412.
  12. Graaumans K., et al. “A cross-sectional study on fatigue, anxiety, and symptoms of depression and their relation with medical status in adult patients with Marfan syndrome. Psychological consequences in Marfan syndrome”. Clinical Genetics (2022): 404-413.
  13. Palamar M., et al. “Bilateral Nasal Ectopia Lentis with no Skeletal Abnormality: Is it Marfan Syndrome?” Turkish Journal of Ophthalmology (2010): 245-247.

Rajnish Raj., et al. "Bilateral Nasal Ectopia Lentis and Major Depressive Disorder in Marfan Syndrome: A Case Report". EC Ophthalmology 14.12 (2023): 01-05.