1Sanatorio Otamendi y Miroli, Universidad de Buenos Aires, Buenos Aires, Argentina
2Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario - CONICET, Argentina
3Oftalmos Centro Oftalmológico de Alta Complejidad, Universidad de Buenos Aires, Buenos Aires, Argentina
Purpose: To evaluate the association between the main bio- markers of Diabetic Macular Edema (DME) and the Visual Acuity (VA), and determine its importance as a prognostic tool at time to start an antiangiogenic treatment in each patient.
Methods: Retrospective, observational and longitudinal cohort study. 25 OCT scans of 23 patients with diabetic macular edema (DME) were analyzed, and the Best Corrected Visual Acuity (BCVA) at baseline and at 3, 6 and 9 months of treatment was registered. Baseline images were evaluated for predominant type of macular edema (cystoid, spongiform, with subfoveal serous detachment, or tractional compromise); presence of outer retinal damage (ORD, considered as any discontinuity in Limiting Extern Membrane, Ellipsoid Zone, and/or Interdigitation Zone); presence of disorganization of the Inner Retinal Layers (DRIL), and Hyperreflective Focus (HF) quantity, as well as Central Macular Thickness (CMT). Correlations between each OCT biomarker and visual acuity gain were analyzed using longitudinal mixed-effects models.
Results: Twenty five eyes with NAIVE DME were included. Baseline best-corrected visual acuity (BCVA) was between 0.3 and 1.3 on a logarithm of minimum angle of resolution visual chart (logMAR). Type of macular edema, DRIL presence, and CMT presented a statistically significant effect on the VA modification along the time (p < 0,001 in all cases). Patients with DRIL showed worse VA in logMAR terms at 9 months than patients without DRIL, being the difference statistically different (p = 0,026), and showed less improvement in VA along the nine months treatment (interaction effect p = 0,007). Eyes with subfoveal serous detachment and eyes with tractional component gained less vision than patients with only cystoid macular edema. There were no statistically significant differences between presence of hyperreflective focus, extern retinal layers alteration and VA along the treatment time.
Conclusion: This study showed that it is useful to assess the initial CMT but not in isolation, and above all the presence of DRIL, which proved to be the tomographic biomarker with the greatest potential as a predictor of clinical response in terms of VA.
Keywords: Diabetic Macular Edema; OCT; Biomarkers; DRIL
Camila Iris Dorrego., et al. Association Between Biomarkers in Optical Coherence Tomography and Visual Acuity in Patients with Edema Diabetic Macular Treated with Antiangiogenics. EC Ophthalmology 14.7 (2023): 01-14.
© 2023 Camila Iris Dorrego., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Open Access by ECronicon is
licensed under a Creative Commons Attribution
4.0 International License
Based on a work at www.ecronicon.net