EC Gynaecology

Earlier we had reviewed comprehensively how there is need for antibiotics therapy for chronic endometritis (CE) prior to IVF/ICSI stimulation in view of better outcomes of IVF/ICSI, with full details of microbiome alterations in endometrium. However recently a report has documented escalated abortion rates subsequent to antibiotics therapy. There the standard diagnostic criteria of ≥ 5 plasma cells/HPF was not used instead ≥ 1 plasma cells in 10 high power fields (HPF)in study of Duan., et al. They found same results on CD 138 Immunohistochemistry. Despite limitations, Cincinelli., et al. observed that new caveats have got stimulated regarding diagnostic criteria, cured testing whether biopsy essential or not and advocated greater prospective studies. However their group further conducted a systematic review and meta-analysis over 10 grp studies and observed better clinical, and ongoing pregnancy rate ([CPR], OPR) along with live birth rates (LBR) with antibiotics therapy prior to IVF/ICSI. Further cured CE had better CPR, OPR along with LBR.

Keywords: Chronic Endometritis; In Vitro Fertilization; Antibiotics Therapy; Live Birth Rates

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