EC Gynaecology

Objective: To analyze the correlation between cytology, colposcopy, and histology in HPV-positive women, focusing on high-risk genotypes 16 and 18.

Methods: A cross-sectional study of 174 hr-HPV-positive women. All underwent cytology, colposcopy (with biopsy if needed), and genotyping. Analysis focused on 96 patients with confirmed histological lesions.

Results: The overall cytology-colposcopy-histology correlation was 87.5%. Overall Sensitivity: Cytology (95.83%), Colposcopy (91.67%). HPV16 (23 cases): 100% correlation for all tests. HPV18 (15 cases): 93.33% correlation (100% cytology, 93.33% colposcopy).

Conclusion: The combination of cytology, universal colposcopy, and HPV genotyping is a highly effective triage strategy. The near-perfect correlation for HPV16/18 confirms their high oncogenic risk and supports using genotyping for risk stratification. This integrated approach enables early identification of high-risk patients, optimizes resources, and guides personalized management to prevent cervical cancer.

 Keywords: Cytology; Colposcopy; HPV16; HPV18; Cervical Cancer; High-Risk Human Papillomavirus (hr-HPV)

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