EC Gynaecology

Purpose: There are limited studies about the impact of some hormones (including LH, P₄) on the number of top quality embryos, which in turn very important to expect the implantation potentials and IVF success. The purpose of our study is to explore the correlations between progesterone (P₄) hormone’s values on the day of trigger, (P₄, LH) hormones’ values on the retrieval day, and how these hormones affect top quality embryos. In addition, this study reveal if endometrial thickness on the retrieval day does effected by or affects those hormones values.

Design and Methods: This study is prospective, single-center study conducted in the department of British Syrian IVF and Fetal Medicine, AL Rasheed Hospital, Syria. This study included 112 Women aged 23 to 45 years old. This study group had IVF according to one of two controlled ovarian stimulation protocols: GnRH antagonist protocol or GnRH agonist suppression protocol (long luteal phase). All the patients used either recombinant, highly purified FSH (GONAL-f^®, Merck KGaA Darmstadt, Germany) alone or in combination with purified urinary hMG (Menotropin, Bharat Serums and Vaccines Ltd, India) for ovarian stimulation. No special considerations were taken for the administration of ovulation stimulation drugs; however, the availability of these drugs in the local market during that period was the controlling factor, particularly considering the local sanctions. The causes of IVF varied between male factor, advanced women age, low ovarian reserve, Tubal factor, intermittent sexual relationship, polycystic ovarian syndrome, preimplantation genetic diagnosis (PGD), or combination of multiple factors. It is worth to mention that donation is prohibited according to our health ministry‘s laws.

Conclusion: In view of the fact that Top quality embryos plays an important role in IVF outcome, our study showed that elevation of number of retrieval oocytes, fertilized ovum, and value of P₄ on retrieval day led to raise of top quality embryos’ number. LH level on retrieval day has no relation with Top quality embryos number. P₄ values raise on trigger day led to raise of the number of embryos but not top quality embryos. Endometrial thickness has no relation with (LH, P₄) on retrieval day, P₄ on trigger day, or top quality embryos.

 Keywords: Progesterone Hormone; LH Hormone; Endometrial Thickness; Top Quality Embryos; Trigger Day; Retrieval Day

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