EC Gynaecology

Research Article Volume 13 Issue 2 - 2024

Prospective Study on the Efficacy and Safety of Uronext® in Parallel Groups in Women with Acute Cystitis

Khodyreva LA1,2, Bernikov AN1,3, Kupriyanov YA1,2,3, Arefieva OA1,2,3, Orešnik M4* and Pushkar DY1,2,3

1Moscow Urological Center on the Basis of Botkin Hospital, Russia

2Research Institute of the Moscow Department of Health, Russia

3Federal State Budgetary Educational Institution of Higher Education “Russian University of Medicine” of the Ministry of Health of the Russian Federation, Russia

4PharmaLinea Ltd., Slovenia

*Corresponding Author: Orešnik M, Science and Research Director, PharmaLinea Ltd., Ljubljana, Slovenia.
Received: December 22, 2023; Published: January 11, 2024




Uncomplicated lower urinary tract infections (LUTI) are one of the most common infections in adult women. LUTI are often relapsing and consequently significantly affect the quality of life of affected population. Antibiotics are treatment of choice in the case of LUTI occurrence, but especially due to the increasing pathogen resistance alternative approaches are being researched. We aimed to evaluate the efficacy and safety of the Qcran®, D-mannose and vitamin D3 based food supplement in women with acute cystitis and its effect on the recurrence of LUTI. We screened 111 female patients aged 18 - 80 years, with active acute cystitis, that was confirmed by a positive bacteriological urine test. Eligible participants were randomized into 2 parallel groups, in a 1:1 ratio, to receive either standard single dose of antibiotic therapy or antibiotic therapy and food supplement. After 12 weeks, proportion of patient without cystitis relapse in the group with scheduled supplementation was significantly higher than in control versus 19,2% (p < 0.0001). By the end of the trial the difference in the mean recurrence of the disease was 0,78 ± 0,63 and reached statistical significance (p < 0.0001). According to ACSS QoL subscale and VAS QoL scale, quality of life significantly improved in the supplement group at all time points, as compared to control group.

Uronext® present a new, effective and well tolerated approach to improved management of LUTI in adult women.

 Keywords: Cystitis; Women; Cranberry; D-Mannose; Supplement; Antibiotic; Recurrence; Quality of Life

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Orešnik M., et al. "Prospective Study on the Efficacy and Safety of Uronext® in Parallel Groups in Women with Acute Cystitis". EC Gynaecology 13.2 (2024): 01-13.

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