EC Gynaecology

Research Article Volume 12 Issue 10 - 2023

Possibilities for Implementing Reproductive Function in Endometrial Cancer, Atypical Endometrial Hyperplasia in PCOS and Infertility

Shumeikina AO1,2,3*, Krasilnikov SE1,2,4, AG Kedrova2,5, AL Chernyshova6 and Pasman NM1

1Federal State Autonomous Educational Institution of Higher Education "Novosibirsk National Research State University", Novosibirsk, Russian Federation

2Institute of Oncology and Neurosurgery of the Federal State Budgetary Institution National Medical Research Center Named ak. E.N. Meshalkin, Novosibirsk, st. Rechkunovskaya, Russia

3Federal State Budget Scientific Institution "Federal Research Center of Fundamental and Translational Medicine", Novosibirsk, st. Timakova, Russia

44Novosibirsk State Medical University, Krasniy Prospect, Novosibirsk, Russia

55FSBI "Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies of the Federal Medical Biological Agency of Russia", Moscow, Orekhovy Boulevard, Russia

66Research Institute of Oncology of the Federal State Budgetary Scientific Institution "Tomsk National Research Medical Center of the Russian Academy of Sciences", Tomsk, per. Cooperative, Russia

*Corresponding Author: Shumeikina AO, Federal State Autonomous Educational Institution of Higher Education "Novosibirsk National Research State University", Novosibirsk, Russian Federation.
Received: September 04, 2023; Published: September 27, 2023

Introduction: The common and key in the pathogenesis of PCOS and chronic endometritis (CE) is the chronic course of inflammation [2-4]. Persistent damage to the endometrium leads to impaired endometrial receptivity and creates conditions for the development of infertility [5,8].

The Purpose of the Study: Was to identify the most common endometrial pathology in women with PCOS and infertility and to analyze the effectiveness of infertility treatment in women with this pathology, to evaluate reproductive outcomes.

Materials and Methods: Analyzed 240 case histories of patients of LLC "Clinic of Professor Pasman", Novosibirsk Clinical Oncological Dispensary for the period 2012-2022, diagnosed with PCOS, Infertility. Patients were included in the study group by random sequential selection.

The frequency of occurrence of each of the PCOS phenotypes was analyzed, as well as the prevalence of endometrial pathology. The most common pathology is chronic endometritis, therefore, in addition to the standard methods of treating infertility in PCOS, CE was additionally treated by the following methods: photodynamic therapy (PDT) and the introduction of a macrophage medium into the uterine cavity.

Results and Discussion: In 61% of cases, hysteroscopy was performed and endometrial pathology was detected, which indicates the need to diagnose the endometrium in women with PCOS, especially before using ART. The most common endometrial pathology is chronic endometritis (61.6%). PDT and the introduction of macrophage medium increase the effectiveness of the treatment of CE and infertility in PCOS. The results obtained indicate a high incidence of PCOS without hyperandrogenism and obesity.

Keywords: PCOS; Infertility; Chronic Endometritis

  1. Bezdenezhnyh EI., et al. “Fotodinamicheskaja terapija v lechenii hronicheskogo jendometrita, associirovannogo s besplodiem”. Sbornik trudov, programma III Mezhdunarodnogo kongressa. Pod red. N.M. Pasman, M.Ju.Denisova (2017): 65-67.
  2. Chernuha GE., et al. “Novye vozmozhnosti korrekcii funkcii reproduktivnoj sistemy pri sindrome polikistoznyh jaichnikov”. Medicinskij Sovet 9 (2015): 34-38.
  3. Jiang NX and Li XL. “The Disorders of Endometrial Receptivity in PCOS and Its Mechanisms”. Reproductive Sciences9 (2022): 2465-2476.
  4. Pathare ADS., et al. “Basic aspects of endometrial receptivity in PCOS patients”. Molecular Biology Reports2 (2022): 1519-1528.
  5. Lazareva LM., et al. “SPKJa v reproduktivnom vozraste: fenotipicheskoe raznoobrazie i diagnosticheskie podhody (obzor literatury)”. Doktor.Ru 19.6 (2020): 50-56.
  6. Nikonov SD., et al. Sposob lechenija hronicheskogo jendometrita (2017).
  7. Chernyh ER., et al. Sposob lechenija hronicheskogo jendometrita (2019).
  8. Sharifulin JeM., et al. “Sostojanie jendometrija pri sindrome polikistoznyh jaichnikov v reproduktivnom vozraste”. Acta Biomedica Scientifica3 (2018): 136-142.
  9. Shan H., et al. “Abnormal Endometri- al Receptivity and Oxidative Stress in Polycystic Ovary Syndrome”. Frontiers in Pharmacology 13 (2022): 904942.
  10. Deswal R., et al. “Cross-sectional study of the prevalence of polycystic ovary syndrome in rural and urban populations”. International Journal of Gynecology and Obstetrics3 (2019): 370-379.
  11. Guo F., et al. “Altered Molecular Pathways and Biomarkers of Endometrial Receptivity in Infertile Women with Polycystic Ovary Syndrome”. Reproductive Sciences (2022).
  12. Tata B., et al. “Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces poly- cystic ovary syndrome in adulthood”. Nature Medicine6 (2018): 834-846.
  13. Bai X., et al. “Research progress of endometrial receptivity in patients with polycystic ovary syndrome: a systematic review”. Reproductive Biology and Endocrinology1 (2021): 122.
  14. Abbara A., et al. “Anti-Müllerian hormone (AMH) in the Diagnosis of Menstrual Disturbance Due to Polycystic Ovarian Syndrome”. Frontiers in Endocrinology 10 (2019): 656.
  15. Zhao J., et al. “An Update on the Progress of Endometrial Receptivity in Women with Polycystic Ovary Syndrome”. Reproductive Sciences8 (2022): 2136-2144.

Shumeikina AO., et al. Possibilities for Implementing Reproductive Function in Endometrial Cancer, Atypical Endometrial Hyperplasia in PCOS and Infertility. EC Gynaecology 12.10 (2023): 01-07.