1Federal State Autonomous Educational Institution of Higher Education "Novosibirsk National Research State University", Novosibirsk, Russian Federation
2Institute of Oncology and Neurosurgery of the Federal State Budgetary Institution National Medical Research Center Named ak. E.N. Meshalkin, Novosibirsk, st. Rechkunovskaya, Russia
3Federal State Budget Scientific Institution "Federal Research Center of Fundamental and Translational Medicine", Novosibirsk, st. Timakova, Russia
44Novosibirsk State Medical University, Krasniy Prospect, Novosibirsk, Russia
55FSBI "Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies of the Federal Medical Biological Agency of Russia", Moscow, Orekhovy Boulevard, Russia
66Research Institute of Oncology of the Federal State Budgetary Scientific Institution "Tomsk National Research Medical Center of the Russian Academy of Sciences", Tomsk, per. Cooperative, Russia
Introduction: The common and key in the pathogenesis of PCOS and chronic endometritis (CE) is the chronic course of inflammation [2-4]. Persistent damage to the endometrium leads to impaired endometrial receptivity and creates conditions for the development of infertility [5,8].
The Purpose of the Study: Was to identify the most common endometrial pathology in women with PCOS and infertility and to analyze the effectiveness of infertility treatment in women with this pathology, to evaluate reproductive outcomes.
Materials and Methods: Analyzed 240 case histories of patients of LLC "Clinic of Professor Pasman", Novosibirsk Clinical Oncological Dispensary for the period 2012-2022, diagnosed with PCOS, Infertility. Patients were included in the study group by random sequential selection.
The frequency of occurrence of each of the PCOS phenotypes was analyzed, as well as the prevalence of endometrial pathology. The most common pathology is chronic endometritis, therefore, in addition to the standard methods of treating infertility in PCOS, CE was additionally treated by the following methods: photodynamic therapy (PDT) and the introduction of a macrophage medium into the uterine cavity.
Results and Discussion: In 61% of cases, hysteroscopy was performed and endometrial pathology was detected, which indicates the need to diagnose the endometrium in women with PCOS, especially before using ART. The most common endometrial pathology is chronic endometritis (61.6%). PDT and the introduction of macrophage medium increase the effectiveness of the treatment of CE and infertility in PCOS. The results obtained indicate a high incidence of PCOS without hyperandrogenism and obesity.
Keywords: PCOS; Infertility; Chronic Endometritis
Shumeikina AO., et al. Possibilities for Implementing Reproductive Function in Endometrial Cancer, Atypical Endometrial Hyperplasia in PCOS and Infertility. EC Gynaecology 12.10 (2023): 01-07.
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