EC Gynaecology

Research Article Volume 12 Issue 6 - 2023

Placental Location and its Maternal and Perinatal Outcome

Veena M Vernekar*, Ashok Kumar and Sreelatha S

Department of Obstetrics and Gynaecology, Rajiv Gandhi University of Health Science, ESIC MC PGIMSR and Model Hospital, Rajajinagar, India

*Corresponding Author: Veena M Vernekar, Department of Obstetrics and Gynaecology, Rajiv Gandhi University of Health Science, ESIC MC PGIMSR and Model Hospital, Rajajinagar, India.
Received: April 20, 2023; Published: May 23, 2023



Background: The human placenta is a complex organ and plays a key role during pregnancy. Normal placentation and placental development are critical for a successful pregnancy. The localisation of the placenta determined by ultrasound in the second trimester has been hypothesised to have an impact on the pregnancy and hence it can be used as a tool to assess the adverse pregnancy outcomes.

Objectives: To assess the relationship between placental location and maternal and perinatal outcomes.

Methods: This is a prospective study conducted at ESIC-MC and PGIMSR Hospital, Bengaluru from January 2020 to June 2021. 350 primigravida attending the antenatal clinic were included in the study. Placental locations was determined by Ultrasound during 18-28 weeks period of gestation. Patients were followed upto term gestation. The maternal and perinatal outcomes was observed.

Results: Among the 350 patients enrolled in the study; the placenta was located laterally in 106 women (30.3%), anteriorly in 96 (27.4%), posteriorly in 96 (27.4%) and fundal in 52 (14.9%) women. 54 (42%) of the study participants with gestational hypertension had laterally located placenta which was statistically significant (p = 0.001). Fundal and lateral placenta had a significant association with malpresentations (p = 0.005). 6 out of 7 pregnant women with abruption had lateral placenta (p = 0.013).

Conclusion: Localisation of placenta by ultrasound in second trimester is an important determinant of pregnancy outcomes. Different placental locations are associated with a number of adverse pregnancy and neonatal outcomes like Preeclampsia, IUGR, preterm labour occur more in lateral placenta. Hence second trimester ultrasound can be used as one of the non invasive predictor of adverse pregnancy and neonatal outcomes.

Keywords: Placental Location; Maternal Outcome; Neonatal Outcome; Lateral Placenta; Ultrasound; Preeclampsia

  1. Chhabra S., et al. “Maternal neonatal outcome in relation to placental location, dimensions in early pregnancy”. Journal of Basic and Clinical Reproductive Sciences 2 (2013): 105.
  2. Zia S. “Placental location and pregnancy outcome”. Journal of the Turkish-German Gynecological Association4 (2013): 190-193.
  3. Preety A., et al. “Study on Relation Between Placental Laterality In Second Trimester Ultrasound and Development of Preeclampsia At Term”. Jemds 104 (2015): 16926-16928.
  4. Magann EF., et al. “Second trimester placental location as a predictor of an adverse pregnancy outcome”. Journal of Perinatology 1 (2007): 9-14.
  5. Granfors M., et al. “Placental location and pregnancy outcomes in nulliparous women: A populationā€based cohort study”. Acta Obstetricia et Gynecologica Scandinavica 98 (2019): 988-996.
  6. Singh N., et al. “To study second trimester placental location as a predictor of adverse pregnancy outcome”. International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6 (2016): 1414-1417.
  7. Nair VV., et al. “Study of placental location and pregnancy outcome”. International Journal of Reproduction, Contraception, Obstetrics and Gynecology 4 (2019): 1393-1397.
  8. Alka Patil., et al. “Study of neonatal outcome in relation to placental location in tertiary care centre”. MedPulse International Journal of Gynaecology 1 (2021): 09-14.
  9. Dhingra S., et al. “Correlation between placental location and maternal fetal outcome”. Obsgyne Review: Journal of Obstetric and Gynecology 3 (2019): 128-132.
  10. Prathima A and Reddi Rani P. “Association of placental position with the development of hypertension in pregnancy”. International Journal of Reproduction, Contraception, Obstetrics and Gynecology 1 (2019): 238.
  11. Nandanwar RA., et al. “The Relation between development of Pregnancy Induced Hypertension and location of placenta among the pregnant women in Bastar Region”. Indian Journal of Clinical Anatomy and Physiology 4 (2015): 169-173.
  12. Seckin KD., et al. “Is lateral localisation of placenta a risk factor for adverse perinatal outcomes?” Journal of Obstetrics and Gynaecology 7 (2015): 696-698.
  13. Faizi S and Pai MV. “Role of Midtrimester Localization of the Placenta in predicting Pregnancy Outcome”. International Journal of Infertility and Fetal Medicine 3 (2014): 8791.
  14. Fung TY., et al. “Placental site in the second trimester of pregnancy and its association with subsequent obstetric outcome”. Prenatal Diagnosis 6 (2011): 548-554.
  15. Kalanithi LEG., et al. “Intrauterine Growth Restriction and Placental Location”. Journal of Ultrasound in Medicine 11 (2007): 1481-1489.
  16. Devarajan K., et al. “Placental location and newborn weight”. Journal of Obstetrics and Gynaecology Canada 4 (2012): 325-329.
  17. Kofinas AD., et al. “The effect of placental location on uterine artery flow velocity waveforms”. American Journal of Obstetrics and Gynecology 6 (1988): 1504-1508.
  18. Bhalerao AV., et al. “Lateral placentation by ultasonography: a simple predictor of preeclampsia”. Journal of South Asian Federation of Obstetrics and Gynaecology 2 (2013): 68-71.
  19. Gizzo S., et al. “Sonographic assessment of placental location: a mere notional description or an important key to improve both pregnancy and perinatal obstetrical care? A large cohort study”. International Journal of Clinical and Experimental Medicine 8 (2015): 13056-13066.
  20. Seadati N., et al. “Placental location at second trimester and pregnancy outcomes”. The Journal of Pharmaceutical and Scientific Innovation 2 (2013): 32-34.
  21. Torricelli M., et al. “Anterior placental location influences onset and progress of labor and postpartum outcome”. Placenta 4 (2015): 463-466.
  22. Schulman H., et al. “Pregnancy surveillance with Doppler velocimetry of uterine and umbilical arteries”. American Journal of Obstetrics and Gynecology 1 (1989): 192-196.
  23. Booth RT., et al. “Significance of site of placental attachment in uterus”. British Medical Journal 5294 (1962): 1732-1734.
  24. Rajeshwari RR and Rubini M. “Maternal and perinatal outcome in placenta previa - one year study in tertiary care center in Tamil Nadu, India”. International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8 (2016): 2819-2822.
  25. Jaisal P and Bhonsale D. “Association of Placental Localization at 16-24 Week and Pregnancy Outcome”. International Journal of Medical Research Professionals 4 (2016): 7-9.
  26. Jackson R., et al. “469: The impact of placental location on neonatal adverse outcomes”. American Journal of Obstetrics and Gynecology 1 (2018): S282.
  27. Contro E., et al. “Unilaterally increased uterine artery resistance, placental location and pregnancy outcome”. European Journal of Obstetrics and Gynecology and Reproductive Biology 2 (2010): 143-147.
  28. Saddler TW. Langmans Medical Embryology, Ninth edition Lippincott Williams and Wilkins Company (2004): 51-134.
  29. Dutta DC. “The placenta and Fetal membranes”. In Dutta DC, edition. Text book of obstetrics including perinatology and contraception,8th edition. Calcutta, India (2015): 32-46.
  30. Kakkar T., et al. “Placental Laterality as a Predictor for Development of Preeclampsia”. The Journal of Obstetrics and Gynecology of India 1 (2013): 22-25.
  31. Gonser M., et al. “Placental location and incidence of preeclampsia”. Ultraschall in der Medizin 17 (1996): 236-238.
  32. , et al. “WilliamsObstetrics25thedition 40 (2018):710.
  33. Donald I. “On launching a new diagnostic science”. American Journal of Obstetrics & Gynecology 103 (1968): 609-628.
  34. Kobayashi M., et al. “Placental localization by ultrasound”. American Journal of Obstetrics and Gynecology 106 (1970): 279.
  35. Metzenbauer M., et al. “Three dimensional ultrasound measurement of the placental volume in early pregnancy: Method and correlation with biochemical placental parameters”. Placenta 22 (2001): 602.
  36. Gude NM., et al. “Growth and function of the normal human placenta”. Thrombosis Research 5-6 (2004): 397-407.
  37. Pai MV and Pillai J. “Placental laterality by ultrasound–a simple yet reliable predictive test for preeclampsia”. The Journal of Obstetrics and Gynecology of India 5 (2005): 431-433.
  38. Olive EC., et al. “Test characteristics of placental location screening by transabdominal ultrasound at 18-20 weeks”. Ultrasound in Obstetrics and Gynecology 7 (2006): 944-949.
  39. Khong TY., et al. “Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for- gestational age infants”. BJOG: An International Journal of Obstetrics and Gynaecology 10 (1986): 1049-1059.
  40. Hoogland HJ and De Haan J. “Ultrasonographic placental localization with respect to fetal position in utero”. European Journal of Obstetrics and Gynecology and Reproductive Biology 11 (1980): 9-15.

Veena M Vernekar., et al. Placental Location and its Maternal and Perinatal Outcome. EC Gynaecology 12.6 (2023): 23-39.