EC Gynaecology

Review Article Volume 13 Issue 1 - 2024

Parthenogenesis: A Contemporary Review and Synopsis of the Medical Perspective of “Immaculate” Conceptions

Dabeluchi C Ngwu1,2, Nicholas A Kerna3,4*, Kevin D Pruitt5,6, ND Victor Carsrud7, Hilary M Holets8, Sudeep Chawla9, John V Flores8, Joseph Anderson II10 and Wail Taha Mohammed Taha11

1FMC Umuahia with King Abdullah Hospital, Bisha, Saudi Arabia

2Earthwide Surgical Missions, Nigeria

3Independent Global Medical Researchers Consortium

4First InterHealth Group, Thailand

5Kemet Medical Consultants, USA

6PBJ Medical Associates, LLC, USA

7Lakeline Wellness Center, USA

8Orange Partners Surgicenter, USA

9Chawla Health and Research, USA

10International Institute of Original Medicine, USA

11School of Medicine, Al Fashir University, Sudan

*Corresponding Author: Nicholas A Kerna, (mailing address) POB47 Phatphong, Suriwongse Road, Bangkok, Thailand 10500. Contact: medpublab+drkerna@gmail.com
Received: August 08, 2023; Published: December 25, 2023



Parthenogenesis is the process by which an ovum (also known as an egg) can develop into an individual without the participation of a male agent. Virgin births are possible in invertebrates and vertebrates such as birds, fish, and reptiles. Although mammals can begin the process of parthenogenesis, they do not typically give birth to parthenogenetic offspring. It has been demonstrated that mice and rabbit embryos can be developed parthenogenetically to a stage equivalent to approximately halfway through pregnancy in laboratory conditions. However, these embryos can then be terminated. According to a recent study, using calcium ionophore as a catalyst, it was possible to activate human embryos through parthenogenesis spontaneously. Parthenogenesis can take many forms, each classified according to the cell division method involved. It was long believed that this event is controlled by a single (master) gene or a single locus with closely linked genes and biomechanical signaling. However, recent research has debunked these long-held beliefs. The process of parthenogenesis could prove helpful in creating regenerative therapies and developing clones that contain favorable gene variants. To generate stem cells for genetic research, scientists have been examining ways to stimulate human egg development before fertilization. This process is done to harvest the stem cells from the eggs. If appropriately designed, therapies based on parthenogenesis can even benefit human health.

 Keywords: Parthenogenesis; Medical Perspective; “Immaculate” Conceptions; Clonal Reproduction; Human Health

  1. Schwander T. “Parthenogenesis”. Oxford Bibliographies in Evolutionary Biology (2014). https://www.oxfordbibliographies.com/display/document/obo-9780199941728/obo-9780199941728-0011.xml
  2. Lawrence CR. “Charles Bonnet (1720-1793)”. Embryo Project Encyclopedia (2009). https://embryo.asu.edu/pages/charles-bonnet-1720-1793
  3. Nogler GA. “Gametophytic apomixis”. In Embryology of Angiosperms, ed. Johri B. M. (Berlin: Springer-Verlag) (1984): 475-518. https://link.springer.com/chapter/10.1007/978-3-642-69302-1_10
  4. Asker SE and Jerling L. “Apomixis in Plants”. Boca Raton FL: CRC Press (1992).
  5. Parthenogenesis - Types and Mechanisms. LiquiSearch (2023).
  6. Lampert KP. “Facultative parthenogenesis in vertebrates: reproductive error or chance?” Sexual Development 6 (2008): 290-301. https://pubmed.ncbi.nlm.nih.gov/19276631/
  7. Ferguson-Smith AC. “Uniparental Inheritance”. Ed: Brenner S, Miller JH. In Encyclopedia of Genetics, Academic Press (2001): 2096-2099. https://www.sciencedirect.com/science/article/abs/pii/B0122270800013513
  8. Wake MH. “Modes of Reproduction Verts: Hermaphroditism, Viviparity, Oviparity, Ovoviviparity: (General Definition with Examples)”. Ed: Skinner MK. In Encyclopedia of Reproduction (Second Edition), Academic Press (2018): 18-22. https://www.sciencedirect.com/science/article/abs/pii/B9780128096338205311
  9. Linder D., et al. “Parthenogenic origin of benign ovarian teratomas”. New England Journal of Medicine 2 (1975): 63-66. https://pubmed.ncbi.nlm.nih.gov/162806/
  10. Strain L., et al. “A human parthenogenetic chimaera”. Nature Genetics 2 (1995): 164-169. https://pubmed.ncbi.nlm.nih.gov/7550344/
  11. Yamazawa K., et al. “Parthenogenetic chimaerism/mosaicism with a Silver-Russell syndrome-like phenotype”. Journal of Medical Genetics 11 (2010): 782-785. https://pubmed.ncbi.nlm.nih.gov/20685670/
  12. Winberg J., et al. “Chimerism resulting from parthenogenetic activation and dispermic fertilization”. American Journal of Medical Genetics Part A 9 (2010): 2277-2286. https://pubmed.ncbi.nlm.nih.gov/20803645/
  13. Giltay JC., et al. “Polymorphic detection of a parthenogenetic maternal and double paternal contribution to a 46, XX/46, XY hermaphrodite”. American Journal of Human Genetics 4 (1998): 937-940. https://pubmed.ncbi.nlm.nih.gov/9529354/
  14. Wilson M., et al. “The clinical phenotype of mosaicism for genome-wide paternal uniparental disomy: two new reports”. American Journal of Medical Genetics Part A 2 (2008): 137-148. https://pubmed.ncbi.nlm.nih.gov/18033734/
  15. Mogie M. “The Evolution of Asexual Reproduction in Plants”. London: Chapman & Hall (1992). https://link.springer.com/book/9780412442209
  16. Bicknell RA. “Isolation of a diploid, apomictic plant of Hieracium aurantiacum”. Sexual Plant Reproduction 10 (1997): 168-172. https://link.springer.com/article/10.1007/s004970050084
  17. Conner JA., et al. “Sequence analysis of bacterial artificial chromosome clones from the apospory-specific genomic region of Pennisetum and Cenchrus”. Plant Physiology 3 (2008): 1396-1411. https://pubmed.ncbi.nlm.nih.gov/18508959/
  18. Manríquez-Morán NL., et al. “Genetic Variation and Origin of Parthenogenesis in the Aspidoscelis cozumela Complex: Evidence from Mitochondrial Genes”. Zoological Science 1 (2014): 14-19. https://pubmed.ncbi.nlm.nih.gov/24410491/
  19. Kono T. “Genomic imprinting is a barrier to parthenogenesis in mammals”. Cytogenetic and Genome Research 1-4 (2006): 31-35. https://pubmed.ncbi.nlm.nih.gov/16575160/
  20. Dong J., et al. “Elucidation of a universal size-control mechanism in Drosophila and mammals”. Cell 130 (2007): 1120-1133. https://pubmed.ncbi.nlm.nih.gov/17889654/
  21. Pennarossa G., et al. “Rho signaling-directed YAP/TAZ regulation encourages 3D spheroid colony formation and boosts plasticity of parthenogenetic stem cells”. Advances in Experimental Medicine and Biology 1237 (2020): 49-60. https://pubmed.ncbi.nlm.nih.gov/31376140/
  22. Bos-Mikich A., et al. “Parthenogenesis and Human Assisted Reproduction”. Stem Cells International (2016): 1970843. https://pubmed.ncbi.nlm.nih.gov/26635881/
  23. Didié M., et al. “Parthenogenetic stem cells for tissue-engineered heart repair”. Journal of Clinical Investigation 3 (2013): 1285-1298. https://pubmed.ncbi.nlm.nih.gov/23434590/
  24. Dighe V., et al. “Heterozygous embryonic stem cell lines derived from nonhuman primate parthenotes”. Stem Cells3 (2008): 756-766. https://pubmed.ncbi.nlm.nih.gov/18192229/
  25. Horii T., et al. “Loss of genomic imprinting in mouse parthenogenetic embryonic stem cells”. Stem Cells1 (2008): 79-88. https://pubmed.ncbi.nlm.nih.gov/17962706/
  26. Kim K., et al. “Histocompatible embryonic stem cells by parthenogenesis”. Science5811 (2007): 482-486. https://pubmed.ncbi.nlm.nih.gov/17170255/

Ngwu DC, Kerna NA, Pruitt KD, Carsrud NDV, Holets HM, Chawla S, Flores JV, Anderson II J, Taha WTM. "Parthenogenesis: A Contemporary Review and Synopsis of the Medical Perspective of “Immaculate” Conceptions". EC Gynaecology 13.1 (2024): 01-08.