EC Gynaecology

Background: COVID 19 has been declared as a global pandemic during 2020 with over 640 million confirmed cases and over 891000 deaths. India has been one of the most severely affected country. However, there are very less study related to sero-prevalence among asymptomatic pregnant population.

Aims and Objectives: To study the prevalence of asymptomatic infection in pregnant women and it’s outcome.

Materials and Methods: This is a prospective study done in Department of Obstetrics and Gynaecology of ESI-PGIMSR and ESI- MC, Joka and Department of Microbiology, between April 2020 to March 2021.A total of 200 pregnant female of all age group and parity were included.

Results: Among 200 pregnant women fifty-two (26%) were seropositive and 148(74%) were negative for anti SARS CoV2 antibody. Pregnancy complication like anaemia (HB < 10), GDM, PIH, APH, IUGR were studied among sero-positive group. Pregnancy outcome like PPROM, preterm labour, mode of delivery and post-partum complication as well as neonatal outcome was studied.

Conclusion: Covid 19 antibody testing to be done routinely in all pregnant woman to isolate asymptomatic infection and to know about burden of infection in this population.

 Keywords: Asymptomatic Infection; Pregnant Women; SARS-CoV-2; Covid 19

1. WHO coronavirus (COVID-19) dashboard (2023).
2. Sero-prevalence study conducted by National Center for Disease Control NCDC, MoHFW, in Delhi, June 2020 (2022).
3. Pal M., et al. “Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): An update”. Cureus3 (2020): e7423.
4. Allotey J., et al. “Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis”. British Medical Journal 370 (2022): m3320.
5. Murhekar MV., et al. “Seroprevalence of IgG antibodies against SARS-CoV-2 among the general population and healthcare workers in India, June-July 2021: A population-based cross-sectional study”. PLoS Medicine12 (2021): e1003877.
6. Gupta P., et al. “SARS‐CoV‐2 prevalence and maternal‐perinatal outcomes among pregnant women admitted for delivery: Experience from COVID‐19‐dedicated maternity hospital in Jammu, Jammu and Kashmir (India)”. Journal of Medical Virology 9 (2021): 5505-5514.
7. Sharma KA., et al. “Seroprevalence of SARS‐CoV‐2 antibodies among first‐trimester pregnant women during the second wave of the pandemic in India”. International Journal of Gynecology and Obstetrics 1 (2023): 74-78.
8. Murhekar MV., et al. “Seroprevalence of IgG antibodies against SARS-CoV-2 among the general population and healthcare workers in India, June-July 2021: A population-based cross-sectional study”. PLoS Medicine12 (2021): e1003877.
9. Allotey J., et al. “Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis”. British Medical Journal 370 (2022): m3320.
10. Örtqvist AK., et al. “The association between maternal characteristics and SARS-CoV-2 in pregnancy: a population-based registry study in Sweden and Norway”. Scientific Reports 1 (2022): 8355.
11. Radan AP., et al. “Gestational diabetes is associated with SARS-CoV-2 infection during pregnancy: A case-control study”. Diabetes and Metabolism 4 (2022): 101351.
12. Bahrami R., et al. “Meta-analysis of the frequency of intrauterine growth restriction and preterm premature rupture of the membranes in pregnant women with COVID-19”. Turkish Journal of Obstetrics and Gynecology 3 (2021): 236-244.
13. Taghavi SA., et al. “Obstetric, maternal, and neonatal outcomes in COVID-19 compared to healthy pregnant women in Iran: a retrospective, case-control study”. Middle East Fertility Society Journal 1 (2021): 17.
14. Bahrami R., et al. “Meta-analysis of the frequency of intrauterine growth restriction and preterm premature rupture of the membranes in pregnant women with COVID-19”. Turkish Journal of Obstetrics and Gynecology 3 (2021): 236-244.
15. Jie Yan., et al. “Coronavirus disease 2019 in pregnant women: a report based on 116 cases”. American Journal of Obstetrics and Gynecology 1 (2020): 111.e1-111.e14.
16. Karasek D., et al. “The association of COVID-19 infection in pregnancy with preterm birth: A retrospective cohort study in California”. Lancet Regional Health - Americas 2 (2021): 100027.
17. Zhang J., et al. “The associated factors of cesarean section during COVID-19 pandemic: a cross-sectional study in nine cities of China”. Environmental Health and Preventive Medicine 1 (2020): 60.
18. Yang R., et al. “Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China”. BMC Medicine 1 (2020): 330.
19. Murphy CA., et al. “The effect of COVID-19 infection during pregnancy; evaluating neonatal outcomes and the impact of the B.1.1.7. variant”. Pediatric Infectious Disease Journal 12 (2021): e475-e481.