EC Gynaecology

Objective: Delayed age at menarche (AAM) can be a useful predictive sign of early decreased ovarian reserve hence oocytes freezing could be offered.

Design and Methods: This is a cross-sectional observational, single-centre study conducted in the department of the British-Syrian IVF and Fetal Medicine Centre, AL Rasheed Hospital, Syria the study initially included 3370 women younger than 38 years who approached fertility clinic between August 2018 and May 2022. This study comprised 3370 women who questioned in their fertility history about menarche age and their current health and lifestyle. Observations were documented and analysis.

Result: Age at menarche was late in women with low ovarian reserve. The research sample consisted of 3370 women between the ages of 20 and 38 years, the Mean ± St.D age was (31.24 ± 4.63), there were 2830 (84.0%) women as study group with AMH < 1.1, included 1730 (61.1%) with Late menarche > 14 years, and in control group 540 (16.0%) women with AMH ≤ 1.1 included 10 (1.9%) with Late menarche > 14 years, we found there is A significant relationship between low AMH and Late menarche (Chi-Square p-value: 0.00 < 0.05).

Conclusion: Delayed AAM (age at menarche) after 14 years old is associated with higher risk of low ovarian reserve at earlier age, our findings suggest an alert to investigate AMH Level at younger if there is late incidence of menarche, hence oocytes freezing could be offered or encouraged to conceive early.

Keywords: Menarche; Anti-Mullerian Hormone (AMH); Ovarian Reserve (OR); Age at Menarche (AAM); DFOR (Diminished Functional Ovarian Reserve)

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