Scientific Director Cum Owner Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
The polycystic ovary syndrome (PCOS) portrays an endocrine impairment correlated with numerous metabolic conditions, inclusive of, insulin resistance (IR), type 2 diabetes mellitus (T2DM), metabolic syndrome (MetS), NAFLD, non alcoholic steatohepatitis (NASH), along with enhanced infertility rate. Recently PCOS has been considered to be a condition with low grade chronic inflammation (LGF) [1,2]. As summarised by Dabravolski., et al.  mitochondrial impairment is substantially responsible for PCOS generation and propagation .
Mitochondrial mutations, impaired mitophagy, diminished ATP generation and liberated ROS further aids in the related symptoms, primarily IR, MetS and obesity generation. Future investigations might focus on acquisition of a greater advantageous insight of the etiological part of nuclear and mitochondrial gene mutations, epigenetic, environmental apart from lifestyle factors on the aetiopathogenesis of PCOS and the associated symptoms.
Kulvinder Kochar Kaur. Advancements in the Etiopathogenesis, Pathophysiology and Treatment of Polycystic Ovary Syndrome (PCOS). EC Gynaecology 12.7 (2023): 20-23.
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