EC Gynaecology

Research Article Volume 11 Issue 8 - 2022

Ectopic Pregnancy: Gynecology Emergency Department Admission Criteria

Radhouane Achour1,2*, Dhekra Trabelsi1, Wajih Abidi1, Yasmine Houmane1, Amira Jarboui3 and Rim Ben Hmid1

1Emergency Department of Maternity and Neonatology Center, Faculty of Medicine of Tunis, El Manar University of Tunis, Tunis, Tunisia

2Research Laboratory for Embryo-Fetal Development Disorder and Placenta (LR18SP05), Tunis, Tunisia

3Military Instruction Hospital of Tunis, Tunis, Tunisia

*Corresponding Author: Radhouane Achour, Research Laboratory for Embryo-Fetal Development Disorder and Placenta (LR18SP05), Emergency Department of Maternity and Neonatology Center, Faculty of Medicine of Tunis, El Manar University of Tunis, Tunis, Tunisia.
Received: July 08, 2022; Published: July 27, 2022



Introduction: The incidence of ectopic pregnancy has increased over the past few years and it still represents one of the main causes of maternal death in the first trimester. It is therefore important to address the issue of early diagnosis and management of this pathology.

Objectives: This work aims to study the means of diagnosis of ectopic pregnancies and the different therapeutic options.

Methods: It is a retrospective study of 50 cases of ectopic pregnancy treated in the CMNT emergency department, over a six-month period from November 01st, 2016 to April 30th, 2017. We consider all the EP in the study.

Results: Among participants, 54% of patients presented at least one risk factor.

The main symptoms that led patients to seek medical attention were pelvic pain in 90% of cases, metrorrhagia in 62% of cases, and amenorrhea in 76% of cases.

Once the diagnosis was suspected, its confirmation relied on βHCG levels and ultrasound confrontation.

The median β-HCG level at the time of the diagnosis of the EP was 2378 mIU/ml. Ultrasound examination showed indirect signs in most cases, such as a thickened endometrium in 10 cases (20%), or a significant peritoneal effusion in 76.31% of cases. An extrauterine gestational sac containing an embryo was found in 4 patients (8%), including 2 cases with positive cardiac activity.

Clinical, biological and ultrasound data helped guide the therapeutic choices of these patients: 84% have undergone surgical treatment and 16% of them had a medical treatment.

Conclusion: The improvement of diagnostic strategies for ectopic pregnancy have led to early detection of this pathology and allowed more conservative medical treatments to be employed. However, ultrasound imaging still has its limitations, and is one of the most operator-dependent imaging.

Keywords: Ectopic Pregnancy (EP); Maternal Death; First Trimester

  1. French-speaking Virtual Medical University. Ectopic pregnancy 18 (2010): 1-22.
  2. Barillier H. “Current management of female infertility in France”. Thesis for the state diploma of doctor in pharmacy, University of Caen Normandy, France (2007).
  3. Gervaise A and Fernandez H. “Therapeutic and diagnostic management of ectopic pregnancies”. Journal of Gynecology Obstetrics and Human Reproduction 39 (2010): F17-F24.
  4. Ardaens Y., et al. “Contribution of ultrasonography in the diagnosis of ectopic pregnancy”. Journal of Gynecology Obstetrics and Human Reproduction 32 (2003): 28-38.
  5. Elito J., et al. “Predictive score for the systemic treatment of unruptured ectopic pregnancy with a single dose of methotrexate”. International Journal of Gynecology and Obstetrics 67 (1999): 75-79.
  6. Bray Madoue G., et al. “Ectopic pregnancy: Epidemiological Aspect and Maternal Prognose at N’Djamena South District Hospital (Chad)”. Kisangani Médical 6 (2015): 111-116.
  7. Panelli DM., et al. “Incidence, diagnosis and management of tubal and non-tubal ectopic pregnancies: a review”. Fertility Research and Practice 1 (2015): 15.
  8. “Recommendations for clinical practice: Management of ectopic pregnancy”. Journal of Gynecology Obstetrics and Human Reproduction 32 (2003): 3S6-3S112.
  9. Buss J and Stucki D. “Ectopic pregnancy: a diagnosis and treatment challenge”. Swiss Medical Forum 5 (2005): 519-524.
  10. Bouyer J. “Ectopic pregnancy epidemiology: incidence, risk factors and consequences”. Journal of Gynecology Obstetrics and Human Reproduction 32 (2003): 8-17.
  11. Boudhraa K., et al. “Ectopic pregnancy: diagnosis and therapeutic management concerning 107 cases”. La lettre du Gynécologue 337 (2008): 5-8.
  12. Oliveira FG., et al. “Rare association of ovarian implantation site for patients with heterotopic and with primary ectopic pregnancies after ICSI and blastocyst transfer”. Human Reproduction 16 (2001): 2227-2229.
  13. Poncelet E., et al. “Ultrasound and MRI in ectopic pregnancy”. Imagerie de la Femme 19 (2009): 171-178.
  14. Monnier-Barbarino P. “Ectopic pregnancy: contribution of paraclinical examinations apart from ultrasonography”. Journal of Gynecology Obstetrics and Human Reproduction 32 (2003): 39-53.
  15. Kenfack B., et al. “Ectopic pregnancy in a semi-rural area in Africa: Epidemiological, clinical and therapeutic aspects about a series of 74 cases treated at the District Hospital of Sangmelima in southern Cameroon”. The Pan African Medical Journal 13 (2012): 71-74.
  16. Lédée-Bataille N. “Materno-fœtal dialogue and human embryo implantation: some evolving concepts”. Journal of Gynecology Obstetrics and Human Reproduction 33 (2004): 564-576.
  17. Female reproductive system. Wikipedia.
  18. Canis M., et al. “Ectopic pregnancy: criteria to decide between medical and surgical treatment”. Journal of Gynecology Obstetrics and Human Reproduction 32 (2003): 54-63.
  19. Guidelines of off-label use of methotrexate, injectable solution, as part of a temporary use authorization (2016): 1-14.
  20. Hoover KW., et al. “Trends in the diagnosis and treatment of ectopic pregnancy in the United States”. Obstetrics and Gynecology 115 (2010): 495-502.

Radhouane Achour., et al. Ectopic Pregnancy: Gynecology Emergency Department Admission Criteria. EC Gynaecology 11.8 (2022): 09-15.