EC Gynaecology

Cervical KC is a major public health problem worldwide.

Its incidence is estimated at 570,000 new cases/year (2018 figure). It is the 4^th female KC in incidence. Cervical KC mortality is 312,000 deaths/year.

This KC can be avoided or prevented by 1 Vaccination which plays an important role in prevention. 2 Screening of preneoplasic lesions and their treatment to avoid evolution towards invasive KC. Which explains the heterogeneous geographical distribution in the world (80% of deaths are recorded in developing countries. Varies between 2.5 to 55 cases per 100,000 women). The risk for a woman to develop cervical KC during her lifetime is 1% in France against 5% in developing countries. This reflects the different screening policies.

80 - 90% of cervical KC is epidermoid carcinoma developed from the malpighian epithelium of the exocol, and in 20% an adenocarcinoma developed from the cylindrical epithelium of the endocol.