EC Gynaecology

Introduction: There is a strong correlation between nonalcoholic fatty liver disease (NAFLD) and increased pulse wave velocity (PWV) which is in association with hypertensive complication, postpartum hemorrhage and preterm birth. This is a case report of PWV and NAFLD progressive changes, also laboratory markers in pregnant women during a 4^th to 3^th gestational week (g.w.) follow-up period with preterm delivery.

Case Presentation: We found by ultrasonography (at 4 g.w.) a mild NAFLD according measured hepatorenal index (HRI) = 1.187 and elevated PWV = 6.37 cm/s in 32-year-old pregnant overweight woman [Body mass index (BMI) = 25.6 kg/m²] with accelerated aminotransferases activity, and impaired glucose and lipid metabolism. The ultrasound examination performed at 31 g.w. found increased BMI by 16%, PWV by 6.4% and HRI by 11.6%. Increased systolic/diastolic blood pressure (10.1%/22.7%) and impaired metabolism of insulin, glucose and lipid were detected, too. The baby boy was born preterm, with normal 5-min and 10-min Apgar score, in 36 g.w.

Conclusion: Increased PWV, NAFLD, impaired metabolism of glucose and lipids, high BMI, insulin resistance and gestational diabetes are risk factors for the premature delivery. Early detection of NAFLD and PWV rise, blood pressure, lipid and glucose metabolism will improve the mother's and newborn's health, and will also contribute to on term deliveries.

Keywords: Non-Alcoholic Fatty Liver Disease; Pulse Wave Velocity; Hepatorenal Index; Preterm Birth; Arterial Stiffness

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