EC Gastroenterology and Digestive System

The subject has been discussed, although not extensively, having, as in all cases, those who defend the process and its detractors.

Fortunately, they are more the first and this article, which is on the side of those who believe in super donors, is a review of how we should act with donors so that they reach the superlative degree of super donors and, with this, guarantee a better response. In the health of those who are undoubtedly more and more sick every day.

We analyze the diverse terminology, which is the basis for a better understanding not only of the super donors but also of the modulation of the microbiome, which ultimately is the most significant, in the different pathologies, that the alteration of the intestinal microbiota generates.

Let's take advantage of the fact that the microbiota is an environmental inheritance and that if we improve it, we will improve our health. A fact that should never be forgotten.

Keywords: Super Donors (SD); Microbiome (Mic); Intestinal microbiota (IM); Modulation of the Microbiome (MM); Fecal Microbiota Transplantation (FMT); Probiotics (Prob)

1. Spisni E., et al. “Natural Compounds in the Modulation of the Intestinal Microbiota: Implications in Human Physiology and Pathology” (2020).
2. Hornung B., et al. “Studying microbial functionality within the gut ecosystem by systems biology”. Genes and Nutrition 5 (2018).
3. Olesen SW and Gerardin Y. “Re-Evaluating the Evidence for Faecal Microbiota Transplantation 'Super-Donors' in Inflammatory Bowel Disease”. Journal of Crohn's and Colitis 3 (2021): 453-461.
4. Clemente JC., et al. “The impact of the gut microbiota on human health: an integrative view”. Cell 6 (2012): 1258-1270.
5. Ma Y., et al. “Donors' experiences and attitudes of fecal microbiota transplantation: An empirical bioethics study from China”. Meta 4 (2022): e62.
6. Slomski A. “Superdonor” Fecal Microbiota Transplant Effective for IBS”. The Journal of the American Medical Association 12 (2020): 1124.
7. Hamilton M. “A rating scale for depression”. Journal of Neurology, Neurosurgery, and Psychiatry 23 (1960): 56-62.
8. Vaughn BP., et al. “Increased Intestinal Microbial Diversity Following Fecal Microbiota Transplant for Active Crohn's Disease”. Inflammatory Bowel Diseases 9 (2016): 2182-2190.
9. Duvallet C., et al. “Framework for rational donor selection in fecal microbiota transplant clinical trials”. PLoS One 10 (2019): e0222881.
10. Open Biome. “Open Biome Quality and Safety Program.” (2019).
11. Bénard MV., et al. “Challenges and costs of donor Screening for fecal microbiota transplantations”. PLoS One 10 (2022): e0276323.
12. Kazemian N., et al. “The trans-kingdom battle between donor and recipient gut microbiome influences fecal microbiota transplantation outcome”. Scientific Reports 10 (2020): 18349.
13. Zaneveld JR., et al. “Stress and stability: applying the Anna Karenina principle to animal microbiomes”. Nature Microbiology 2 (2017): 17121.
14. He R., et al. The interplay of gut microbiota between donors and recipients determines the efficacy of fecal microbiota transplantation (2022).
15. Ma Y., et al. “Ethical Issues in Fecal Microbiota Transplantation in Practice”. The American Journal of Bioethics 5 (2017): 34-45.
16. Bibbò S., et al. “Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor”. Journal of Clinical Medicine 6 (2020): 1757.
17. Wang X and Wu M. “Research progress of gut microbiota and frailty Syndrome”. Open Medicine 1 (2021): 1525-1536.
18. MacLellan AD., et al. “Age-Matching in Pediatric Fecal Matter Transplants”. Frontiers in Pediatrics 9 (2021): 603423.
19. Hourigan S and Oliva-Hemker M. “Fecal microbiota transplantation in children: A brief review”. Pediatric Research 80 (2016): 2-6.
20. Zhuang L., et al. “Intestinal Microbiota in Early Life and Its Implications on Childhood Health”. Genomics Proteomics Bioinformatics 1 (2019): 13-25.
21. Ramai D., et al. “Fecal microbiota transplantation: donor relation, fresh or frozen, delivery methods, cost- effectiveness”. Annals of Gastroenterology 1 (2019): 30-38.
22. Ren R., et al. “Long-Term Efficacy of Low-Intensity Single Donor Fecal Microbiota Transplantation in Ulcerative Colitis and Outcome-Specific Gut Bacteria”. Frontiers in Microbiology 12 (2021): 742255.
23. Hamilton M. “A rating scale for depression”. Journal of Neurology, Neurosurgery, and Psychiatry 23 (1960): 56-62.
24. Almeida C., et al. “Current Trends and Challenges of Fecal Microbiota Transplantation-An Easy Method That Works for All?” Biomedicines 10 (2022): 2742.
25. Olekhnovich EI., et al. “Separation of Donor and Recipient Microbial Diversity Allows Determination of Taxonomic and Functional Features of Gut Microbiota Restructuring following Fecal Transplantation”. American Society for Microbiology 4 (2021).