EC Gastroenterology and Digestive System

Eosinophilic esophagitis (EoE) is a chronic disease with symptoms and histological features that usually disappear with treatment.

In EoE, It is challenging to locate works that evaluate adherence to treatment, long-term efficacy, and safety in the literature. Therefore, this work aims To study commitment to therapy, effectiveness, and security.

A prospective, descriptive, and observational study in patients with EoE. Adherence to the initial treatment, when it was not interrupted for more than one week/month until it subsided. Adherence to maintenance treatment when it was not interrupted for more than 1 month/year. Response to treatment when the symptoms and the histology had remitted. Adverse effects were detected in reviews performed at 4, 8, and 12 months and 1 revision/year.

386 patients had EoE. The mean age: 35, 75% male, 83% atopic, 82% respiratory allergy, 11% atopic dermatitis, and 31% food allergy. The time of evolution of the symptoms was 6 years and 8 months, with 87% dysphagia, 27% impactions, and 12.5% other signs of esophageal dysfunction-1/3 of patients’ nonadherence. Initial treatment, 2/3 swallowed topical fluticasone responded, and about half responded to diet therapy or proton pump inhibitors. During maintenance treatment, adherence decreased in the group with diet therapy, and adverse effects were few, mild, and quickly resolved.

Keywords: Eosinophilic Esophagitis; Treatments¸ Adherence; Response; Adverse Events

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