EC Gastroenterology and Digestive System

Research Article Volume 11 Issue 4 - 2024

Role of Kupfer Cells in the Endothelium-Dependent Mechanisms of Liver Reperfusion Injury

Khadasouski MN*

Department of Pathophysiology, Grodno State Medical University, Grodno, Belarus
*Corresponding Author: Khadasouski MN, Department of Pathophysiology, Grodno State Medical University, Grodno, Belarus.
Received: March 05, 2024 Published: March 25, 2024




The prooxidant-antioxidant balance during liver ischemia-reperfusion in rats was investigated after administration of a Kupffer cell blocker - gadolinium (III) chloride - and/or NO synthase inhibitor - L-NAME. It was detected, that Kupffer cells potentiate endothelial dysfunction by activating free radical processes and disrupt the production of nitrogen monoxide during liver ischemia-reperfusion.

 Keywords: Kupffer Cells; Nitrogen Monoxide (NO); Hepatic Ischemia-Reperfusion (HIR)

Khadasouski MN. “Role of Kupfer Cells in the Endothelium-Dependent Mechanisms of Liver Reperfusion Injury ".  11.4 (2024): 01-03.

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