EC Gastroenterology and Digestive System

<Purpose of the Study: The purpose of this study is to establish the possible gastro- and duodenoprotective effect of celecoxib in normal and experimental gastric and duodenal ulcers.

Research Methodology: The experiments were carried out on 12 Wistar rats. Previously, celecoxib was administered to rats for 10 days. Electromyography (EMG) of the antral and fundal parts of the stomach and ascending duodenum was recorded using a Nihon Kohen electromyograph (Japan).

A model of gastric and duodenal ulcers was created by applying 100% acetoacetic acid to the serous lining of the stomach and intestines.

Results and Conclusion: The effect of nonsteroidal anti-inflammatory drugs on the electromotor activity of the smooth muscles of the stomach and duodenum of a rat was studied in normal and when modeling gastric and duodenal ulcers. Cyclooxygenase blockers have been shown to increase the electromotor activity of the gastroduodenal complex and accelerate reparative processes in the area of gastric and duodenal ulcers.

 Keywords: Nonsteroidal Anti-Inflammatory Drugs; Stomach Ulcer

1. Muller N., et al. “The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine”. Molecular Psychiatry 7 (2006): 680-684.
2. Muller N., et al. “Psychotropic effects of COX-2 inhibitors--a possible new approach for the treatment of psychiatric disorders”. Pharmacopsychiatry6 (2004): 266-269.
3. Karadas B., et al. “Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception”. European Journal of Pharmacology 1-3 (2007): 62-68.
4. Devillier P. “Pharmacology of non-steroidal anti-inflammatory drugs and ENT pathology”. La Presse Médicale 30(39-40 Pt 2) (2001): 70-79.