EC Gastroenterology and Digestive System

Introduction: Peptic ulcer disease is a chronic recurrent disease prone to progression and caused by a disorder of the general and local mechanisms of nervous and humoral regulation of the main functions of the gastroduodenal system.

Aim of the Study: The aim is to model two acid-dependent diseases - DC ulcers and pancreatitis (P).

Materials and Methods: The experiments were carried out on 22 Wistar rats with a body weight of 220 - 240g, which are in vivarium conditions with free access to food and water. In gentle conditions, an upper-median laparotomy was performed on an animal fixed on its back, the bulbar section of the DC was removed into the wound and 0.05 ml of 100% glacial acetic acid was applied to the serous membrane using an applicator. The wound was sutured in layers. After 5 days, a relaparotomy was performed under gentle conditions and 0.1 ml of 50% picrylsulfonic acid was injected into the pancreatic duct. After 5 days, the motor function of the fundal and antral sections of the stomach, DC and pancreatic duct was recorded. Next, the animals were divided into 2 groups: the first was a model of DC and P ulcers, the second was correction of DC and P ulcers with serotonin at a dose of 100 mcg/kg.

Results: The motor function of the gastrointestinal tract was recorded 10 days after modeling of DC and P ulcers electromyographically (EMG) in animals of both groups. The amplitude-frequency characteristics of slow waves and spikes, the power of tonic and phase contractions, and propulsive activity were recorded on the EMG curve. The control group consisted of 6 animals of comparable body weight. The statistical analysis was performed using the Mann-Whitney small sample method at p < 0.05.

Conclusion: Electromyographic studies in comorbid experimental pathology show the spread from the focus of excitation in the bulbar department of the DC (the area of the ulcer) gradually fading antegrade and retrograde excitation waves. In comorbid pathology, antroduodenal coordination is disrupted, the administration of serotonin gradually restores it. The propulsive activity of the pancreatic duct in comorbid pathology is repeatedly increased, which supports the inflammatory process in the bulbar department of the pancreas and pancreas: the introduction of serotonin reduces the motor function of the pancreatic duct by 3.7 times, that is, it has a cytoprotective effect. Electromyography as a research method can be used to assess the motor function of the stomach, DC and pancreatic duct in comorbid pathology.

 Keywords: Duodenal Ulcer; Pancreatic Duct; Electromyography; Peptic Ulcer Disease

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