EC Gastroenterology and Digestive System

Mini Review Volume 10 Issue 6 - 2023

Atypical Hemolytic Uremic Syndrome: To What Extent is the Gastrointestinal System Involved?

Harshavardhan Sanekommu1*, Sobaan Taj1, Rida Mah Noor2, Muhammad Umair Akmal3, Reza Akhtar4, Mohammad Hossain1 and Arif Asif1

1Department of Medicine 1945 NJ-33, Jersey Shore University Medical Center, Neptune City, New Jersey, USA

2International University of Kyrgyzstan-International School of Medicine, Eastern Campus, Bishkek, Kyrgyzstan

3Kazakh National Medical University Almaty, Kazakhstan

4Department of Gastroenterology 1945 NJ-33, Jersey Shore University Medical Center, Neptune City, New Jersey, USA

*Corresponding Author: Harshavardhan Sanekommu, Internal Medicine Resident, Department of Medicine 1945 NJ-33, Jersey Shore University Medical Center, Neptune City, New Jersey, USA.
Received: April 23, 2023; Published: May 19, 2023

Microangiopathic hemolytic anemia, thrombocytopenia, and abrupt renal failure are the hallmarks of the uncommon and potentially fatal atypical hemolytic uremic syndrome (aHUS). In addition to renal involvement, the gastrointestinal system is frequently affected in aHUS, with symptoms ranging from mild abdominal pain to severe gastrointestinal bleeding. This review article aims to provide a comprehensive overview of aHUS and its association with gastrointestinal complications. In this article, we explore the pathophysiology of aHUS, its clinical manifestations and examine the various gastrointestinal complications associated with aHUS, including gastrointestinal bleeding, pancreatitis, liver and gallbladder injury and inflammatory bowel disease. Finally, the article raises awareness of aHUS-associated gastrointestinal complications and highlights the need for further research in this area.

Keywords: Hemolytic Uremic Syndrome, Atypical; Nonenteropathic HUS; Gastrointestinal Hemorrhages; Inflammatory Bowel Disease; Acute Pancreatitis

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Harshavardhan Sanekommu., et al. "Atypical Hemolytic Uremic Syndrome: To What Extent is the Gastrointestinal System Involved?". EC Gastroenterology and Digestive System  10.6 (2023): 16-20.