EC Gastroenterology and Digestive System

Microangiopathic hemolytic anemia, thrombocytopenia, and abrupt renal failure are the hallmarks of the uncommon and potentially fatal atypical hemolytic uremic syndrome (aHUS). In addition to renal involvement, the gastrointestinal system is frequently affected in aHUS, with symptoms ranging from mild abdominal pain to severe gastrointestinal bleeding. This review article aims to provide a comprehensive overview of aHUS and its association with gastrointestinal complications. In this article, we explore the pathophysiology of aHUS, its clinical manifestations and examine the various gastrointestinal complications associated with aHUS, including gastrointestinal bleeding, pancreatitis, liver and gallbladder injury and inflammatory bowel disease. Finally, the article raises awareness of aHUS-associated gastrointestinal complications and highlights the need for further research in this area.

Keywords: Hemolytic Uremic Syndrome, Atypical; Nonenteropathic HUS; Gastrointestinal Hemorrhages; Inflammatory Bowel Disease; Acute Pancreatitis

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