EC Gastroenterology and Digestive System

Review Article Volume 12 Issue 2 - 2025

Are Biotics and Fecal Microbiota Transplantation Useful in Chronic Stress?

Álvaro Zamudio Tiburcio1*, Héctor Bermúdez Ruiz2, Silverio Alonso López3 and Pedro Antonio Reyes López4

1Department of Gastroenterology, Intestinal Microbiota Transplantation Medical Specialties Naples Unit, Mexico
2Endoscopy Service, Oncology Hospital, National Medical Center, XXI Century, Mexican Social Security Institute, Hospital Trinidad, Mexico City, Mexico
3Department of Urologist, Chairman Medical Specialties Naples in Mexico City, Mexico
4Immunologist, Rheumatologist, National Institute of Cardiology “I. Chávez”, Mexico City, Mexico
*Corresponding Author: Álvaro Zamudio Tiburcio, Department of Gastroenterology, Intestinal Microbiota Transplantation Medical Specialties Naples Unit, Mexico.
Received: February 10, 2025; Published: March 21, 2025




Chronic stress is defined, its clinical data are presented, its relationship with the intestinal microbiota consists of, and the effect of biotics and fecal microbiota transplantation on this pathology.

Keywords: Chronic Stress (CS); Gut Microbiota (GM); Biotics (Biot); Fecal Microbiota Transplantation (FMT)

  1. World Health Organization. “Stress”. Q&A (2023).
  2. Duszynski-Goodman L and Spam RT. “What is chronic stress? Definition, symptoms, and treatment”. Forbes (2024).
  3. Morera LP., et al. “Biomarkers in stress measurement: A systematic review”. Ansiedad y Estrés 25.1 (2019): 49-58.
  4. Dhama K., et al. “Biomarkers in stress related diseases/disorders: diagnostic, prognostic, and therapeutic values”. Frontiers in Molecular Biosciences 6 (2019): 91.
  5. Liu YZ., et al. “Inflammation: The common pathway of stress-related diseases”. Frontiers in Human Neuroscience 11 (2017): 316.
  6. Vodovotz Y., et al. “A multiscale inflammatory map: linking individual stress to societal dysfunction”. Frontiers in Science 1 (2024): 1239462.
  7. Bower JE and Kuhlman KR. “Psychoneuroimmunology: An introduction to immune-to-brain communication and its implications for clinical psychology”. Annual Review of Clinical Psychology 19 (2023): 331-359.
  8. Madison A and Kiecolt-Glaser JK. “Stress, depression, diet, and the gut microbiota: human-bacteria interactions at the core of psychoneuroimmunology and nutrition”. Current Opinion in Behavioral Sciences 28 (2019): 105-110.
  9. Gabriel SS Tofani., et al. “Gut microbiota regulates stress responsivity via the circadian system”. Cell Metabolism 37.1 (2025): 138-153.e5.
  10. Ling Q., et al. “The role of gut microbiota in chronic restraint stress-induced cognitive deficits in mice”. BMC Microbiology 24.1 (2024): 289.
  11. Appleton J. “The gut-brain axis: influence of microbiota on mood and mental health”. Integrative Medicine (Encinitas) 17.4 (2018): 28-32.
  12. Zhang Y., et al. “Stress triggers gut dysbiosis via CRH-CRHR1-mitochondria pathway”. npj Biofilms Microbiomes 10.1 (2024): 93.
  13. Weiss GA and Hennet T. “Mechanisms and consequences of intestinal dysbiosis”. Cellular and Molecular Life Sciences 74.16 (2017): 2959-2977.
  14. Leigh SJ., et al. “The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective”. Journal of Physiology 601.23 (2023): 4491-4538.
  15. Chang H., et al. “Stress-sensitive neural circuits change the gut microbiome via duodenal glands”. Cell 187.19 (2024): 5393-5412.e30.
  16. Descamps HC., et al. “The enteric nervous system relays psychological stress to intestinal inflammation”. Cell 186.13 (2023): 2823-2838.e20.
  17. Hong H., et al. “Comprehensive metagenomic analysis of stress-resistant and sensitive Listeria monocytogenes”. Applied Microbiology and Biotechnology 107.19 (2023): 6047-6056.
  18. Yue Tao., et al. “Metagenomic study of carbon metabolism in black soil microbial communities under lead-lanthanum stress”. Journal of Hazardous Materials 446 (2023): 130666.
  19. Guazzaroni ME., et al. “Identification and functional analysis of novel stress-resistance genes from metagenomes of extreme environments”. ResearchGate (2023).
  20. Marx W., et al. “Diet and depression: exploring the biological mechanisms of action”. Molecular Psychiatry 26.1 (2021): 134-150.
  21. Schrader C and Ross A. “A review of PTSD and current treatment strategies”. Missouri Medicine 118.6 (2021): 546-551.
  22. Barry DT., et al. “Conventional and unconventional treatments for stress among methadone-maintained patients: treatment willingness and perceived efficacy”. American Journal on Addictions 20.2 (2011): 137-142.
  23. Berding K., et al. “A specific dietary fibre supplementation improves cognitive performance-an exploratory randomised, placebo-controlled, crossover study”. Psychopharmacology (Berl) 238.1 (2021): 149-163.
  24. Vitellio P., et al. “Probiotics in psychosocial stress and anxiety. A systematic review”. Journal of Gastrointestinal and Liver Diseases 29.1 (2020): 77-83.
  25. Ma T., et al. “Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota”. Neurobiology of Stress 14 (2021): 100294.
  26. Berding K., et al. “Feed your microbes to deal with stress: a psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population”. Molecular Psychiatry 28.2 (2023): 601-610.
  27. Rao J., et al. “Fecal microbiota transplantation ameliorates gut microbiota imbalance and intestinal barrier damage in rats with stress-induced depressive-like behavior”. European Journal of Neuroscience 53.11 (2021): 3598-3611.
  28. Gabriel SS., et al. “I “Gut” Rhythm: the microbiota as a modulator of the stress response and circadian rhythms”. FEBS Journal (2025).
  29. Kilinçarslan S and Evrensel A. “The effect of fecal microbiota transplantation on psychiatric symptoms among patients with inflammatory bowel disease: an experimental study”. Actas Españolas de Psiquiatría 48.1 (2020): 1-7.

Álvaro Zamudio Tiburcio., et al. “Are Biotics and Fecal Microbiota Transplantation Useful in Chronic Stress?”.  12.2 (2025): 01-07.

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