EC Gastroenterology and Digestive System

A 61 year old male patient has been complaining of looking older than his peers for about 3 years. He self referred to different hospitals in search of the cause and the response among the clinicians was negative for the cause. His quest was never met, until when diagnosed to have low HB of 8 g/dl after a period of 3 years, in search for the cause of anemia colonoscopy and CT scan revealed to have circumferential narrowing of the ascending colon with local mesenteric and lymph nodes invasion. After right hemicolectomy, histological examination demonstrated moderate differentiated adenocarcinoma and currently the patient is undergoing intensive chemotherapy. Therefore, this case is important in creating awareness on this important but seemingly silent sign of accelerated aging than normal.

 Keywords: Anemia Colonoscopy; CT Scan; Lymph Nodes Invasion

1. Axman R., et al. “Age as a risk factor for colorectal carcinoma”. JNSS1-2 (2011): 28-36.
2. Koo JH., et al. “Improved survival in young women with colorectal cancer”. The American Journal of Gastroenterology6 (2008): 1488-1495.
3. Koo JH and Leong RW. “Sex differences in epidemiological, clinical and pathological characteristics of colorectal cancer”. Journal of Gastroenterology and Hepatology1 (2010): 33-42.
4. Australian Institute of Health and Welfare and Australasian Association of Cancer Registries, Cancer in Australia: An Overview 2007, 2007, Australian Institute of Health and Welfare and Australasian Association of Cancer Registries, Canberra, Australia.
5. Brenner H., et al. “Gender differences in colorectal cancer: implications for age at initiation of screening”. British Journal of Cancer5 (2007): 828-831.
6. Soliman AS., et al. “Colorectal cancer in Egyptian patients under 40 years of age”. International Journal of Cancer1 (1997): 26-30.
7. Prentice AM. “The emerging epidemic of obesity in developing countries”. International Journal of Epidemiology1 (2006): 93-99.
8. Shayo GA and Mugusi FM. “Prevalence of obesity and associated risk factors among adults in Kinondoni Municipal District, Dar es Salaam Tanzania”. BMC Public Health1 (2011): 365.
9. Wolin KY., et al. “Change in physical activity and colon cancer incidence and mortality”. Cancer Epidemiology Biomarkers and Prevention12 (2010): 3000-3004.
10. Lee KJ., et al. “Physical activity and risk of colorectal cancer in Japanese men and women: the Japan Public Health Center-based prospective study”. Cancer Causes and Control 2 (2007): 199-209.
11. Jagoe K., et al. “Tobacco smoking in Tanzania, East Africa: population based smoking prevalence using expired alveolar carbon monoxide as a validation tool”. Tobacco Control3 (2002): 210-214.
12. Parajuli R., et al. “The increased risk of colon cancer due to cigarette smoking may be greater in women than men”. Cancer Epidemiology Biomarkers and Prevention5 (2013): 862-871.
13. Haggar FA and Boushey RP. “Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors”. Clinics in Colon and Rectal Surgery4 (2009): 191-197.
14. Zisman AL., et al. “Associations between the age at diagnosis and location of colorectal cancer and the use of alcohol and tobacco: implications for screening”. Archives of Internal Medicine6 (2006): 629-634.
15. Mayige M., et al. “Non communicable diseases in Tanzania: a call for urgent action”. Tanzania Journal of Health Research5 (2011): 378-386.
16. WHO, Promoting fruit and vegetable consumption around the world, Global Strategy on Diet, Physical Activity and Health.
17. World Bank, Country Overview Tanzania. Country overview(2015).
18. Amine E., et al. Diet, nutrition and the prevention of chronic diseases, Report of a Joint WHO/FAO Expert Consultation, 2002, World Health Organization, Geneva, Switzerland.