EC Dental Science

Introduction: Traumatic ulcerative granulomatosis with stromal eosinophilia (TUGSE) is a rare, benign, reactive and self-limiting lesion always be presented in the mucosa of oral cavity Aim: Reporting a case of traumatic ulcerative granulomatosis with stromal eosinophilia related to sharp broken tooth mimicking squamous cell carcinoma

Case presentation: 61 years old , female patient , medically free, refer to oral medicine clinical because she complaint for lesion in lateral side of tongue since 3 month, the clinical examination shows nodular lesion with rolled margin cover by fibrin membrane

Clinical differential diagnosis: traumatic ulcerative granulomatosis and squamous cell carcinoma Biopsy was taken and result shows the final diagnosis it was traumatic ulcerative granulomatosis with stromal eosinophilia, extraction of the broken tooth was done and topical corticosteroid (clobetasol proponite .05% ) was given 1 time a day for 5 days to apply it over the lesion, follow up after 7 days show rapid regression for the lesion and almost complete healing shown in area of the lesion

Conclusion: The present case shows oral ulcerative lesion that mimic squamous cell carcinoma, finial diagnosis confirmed by biopsy and it was Traumatic ulcerative granuloma with stromal eosinophilia related to Sharp Broken Tooth, the extraction was done for Brocken tooth and topical corticosteroid given to improve the healing of the lesion

 Keywords: Traumatic ulcer, TUGSE , squamous cell carcinoma

1. Banerjee Abhishek., et al. "Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE): a rare self-healing oral mucosal lesion”. BMJ Case Reports8 (2021): e245097.
2. Marszałek Andrzej and Izabela Neska-Długosz. "Traumatic ulcerative granuloma with stromal eosinophilia. A case report and short literature review”. Polish Journal of Pathology3 (2011): 172-175.
3. S Shah Ashna., et al. "Clinical considerations associated with traumatic ulcerative granuloma with stromal eosinophilia”. International Journal of Dermatology7 (2022): e272-e274.
4. Butler Jason N and Todd T Kobayashi. "Traumatic ulcerative granuloma with stromal eosinophilia: a malignant-appearing benign lesion”. Cutis2 (2017): E28-E31.
5. Aizic A., et al. "Traumatic ulcerative granuloma with stromal eosinophilia: CD30 analysis and clonality for T cell receptor gene re-arrangement”. Acta Histochemica8 (2019): 151450.
6. Shen Wei-Ren., et al. "Oral traumatic ulcerative granuloma with stromal eosinophilia: A clinicopathological study of 34 cases”. Journal of the Formosan Medical Association9 (2015): 881-885.
7. Correia-Neto., et al. "Traumatic ulcerative granuloma with stromal eosinophilia mimicking a squamous cell carcinoma”. Journal of Clinical and Experimental Dentistry3 (2024): e377.
8. Shapiro L and EA Juhlin. "Eosinophilic ulcer of the tongue: report of two cases and review of the literature”. Dermatologica4 (1970): 242-250.
9. Sharma BhuShan., et al. "Traumatic ulcerative granuloma with stromal eosinophila: a case report and review of pathogenesis”. Journal of Clinical and Diagnostic Research: JCDR10 (2016): ZD07-ZD09.
10. Benitez Benito., et al. "Traumatic ulcerative granuloma with stromal eosinophilia—clinical case report, literature review, and differential diagnosis”. World Journal of Surgical Oncology 17 (2019): 1-6.
11. Alobeid Bachir., et al. "Eosinophil-rich CD30+ lymphoproliferative disorder of the oral mucosa: a form of “traumatic eosinophilic granuloma””. American Journal of Clinical Pathology1 (2004): 43-50.
12. Doyle John L., et al. "Eosinophilic ulcer”. Journal of Oral and Maxillofacial Surgery4 (1989): 349-352.
13. SahanaPushpa Thaneraj and Rajendran Balamurugan. "Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE): a rare presentation and case report”. Canadian Journal of Dental Hygiene1 (2022): 39-41.
14. Fonseca Felipe Paiva., et al. "Clinicopathological and immunohistochemical analysis of 19 cases of oral eosinophilic ulcers”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology4 (2013): 532-540.