EC Dental Science

Sclerosing polycystic adenoma is an exceptionally discerned neoplasm arising from salivary glands. Initially scripted in 1996, aforesaid lesion is postulated to emerge as a neoplastic lesion. Additionally designated as sclerosing polycystic adenosis, sclerosing adenosis, polycystic adenosis or sclerosing polycystic sialadenopathy, neoplasm recapitulates morphological alterations of fibrocystic change or sclerosing adenosis of mammary glands. Tumefaction is comprised of irregular dissemination of ducts and acini layered by dual epithelium and encompassed within a sclerotic stroma.

1. Rashad R and Barakat A. “A challenging case of sclerosing polycystic adenoma of the parotid gland: a case report and brief review of the latest updates”. Journal of Histotechnology 2 (2024): 87-91.
2. de Carvalho Kimura T., et al. “Clinicopathological profile of sclerosing polycystic adenoma/adenosis: A systematic review”. Head and Neck9 (2023): 2449-2457.
3. Skálová A., et al. “Update from the 5^th edition of the world health organization classification of head and neck tumors: salivary glands”. Head and Neck Pathology 1 (2022): 40-53.
4. Skálová A., et al. “Sclerosing polycystic adenoma of salivary glands: a novel neoplasm characterized by PI3K-AKT pathway alterations-new insights into a challenging entity”. American Journal of Surgical Pathology 2 (2022): 268-280.
5. Hernandez-Prera JC., et al. “Sclerosing polycystic adenoma: conclusive clinical and molecular evidence of its neoplastic nature”. Head and Neck Pathology 2 (2022): 416-426.
6. Wu L., et al. “Sclerosing polycystic adenosis of the submandibular gland: Two case reports”. World Journal of Clinical Cases 12 (2021): 2930-2936.
7. Bishop JA., et al. “Sclerosing polycystic "adenosis" of salivary glands: a neoplasm characterized by PI3K pathway alterations more correctly named sclerosing polycystic adenoma”. Head and Neck Pathology 3 (2020): 630-636.
8. Image 1 Courtesy: Pathology outlines.
9. Image 2 Courtesy: Asian Archives of Pathology.